Heterogeneity of the humoral anti-HCV/E2 response in persistently infected patients as demonstrated by divergent patterns of inhibition of the binding of anti-HCV/E2 human monoclonal antibodies

N. Mancini, F. Canducci, S. Carletti, E. Berardinelli, G. Serafini, A. Grieco, M. Perotti, G. Malcangi, M. G. Danieli, P. E. Varaldo, M. Clementi, Roberto Burioni

Research output: Contribution to journalArticle

Abstract

A complete understanding of the molecular features of humoral immune response could be of pivotal importance in the management of persistent viruses as HCV. In this study, 24 HCV-positive samples, characterized by classical virological parameters, are evaluated using a new assay for the quantitation of antibody subpopulations directed against discrete epitopes on surface glycoprotein E2, a key viral protein. The results, besides confirming the usefulness of this new approach, highlight the extreme heterogeneity of anti-HCV/E2 response as far as single epitopes are concerned. The specific epitopes under study are also demonstrated to be widely shared among different genotypes.

Original languageEnglish
Pages (from-to)183-187
Number of pages5
JournalJournal of Biological Regulators and Homeostatic Agents
Volume17
Issue number2
Publication statusPublished - Apr 2003

Keywords

  • Antibody response
  • Fab inhibition titer
  • HCV/E2
  • Monoclonal fab

ASJC Scopus subject areas

  • Immunology
  • Endocrinology, Diabetes and Metabolism
  • Endocrinology
  • Physiology (medical)
  • Medicine (miscellaneous)
  • Physiology
  • Agricultural and Biological Sciences(all)

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