Abstract
Thyroid hormones (FT3, FT4) and thyroid-stimulating hormone (TSH) were evaluated in a population of 672 well-characterized Italian subjects (age range: 52-113 years), including an unprecedented number of centenarians, semi-supercentenarians, as well as centenarian's offspring and age-matched elderly (CENT, 105+, CENTOFF, and CTRL, respectively). The results show that FT3 level and FT3/FT4 ratio decrease while FT4 and TSH increase in an age-dependent manner. In CENT/105+, higher FT4 level, and lower FT3/FT4 ratio are associated with an impaired functional status and an increased mortality. A cluster analysis identified three clusters of CENT/105+ based on their FT3, FT4, and TSH levels. Cluster 3, characterized by lower FT3 and TSH and higher FT4, shows the worst health status and the shortest survival. Thus, the age-related changes of thyroid hormones extend to the most advanced age, and CENT/105+ are highly heterogeneous regarding thyroid function. This heterogeneity is related to different health, functional and cognitive status, as well as with survival/mortality in CENT/105+. Finally, we investigated a remarkable number of CENT/105+ showing a thyroid profile suggestive of non-thyroidal illness syndrome (NTIS) (excluded from the previous analysis). NTIS CENT/105+ are characterized by a worse functional and cognitive status and an increased mortality with respect to CENT/105+ without NTIS.
| Original language | English |
|---|---|
| Pages (from-to) | 802-810 |
| Number of pages | 9 |
| Journal | The journals of gerontology. Series A, Biological sciences and medical sciences |
| Volume | 74 |
| Issue number | 6 |
| DOIs | |
| Publication status | Published - May 16 2019 |
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Keywords
- Health
- Human aging
- Longevity
- Mortality
- Thyroid hormones
ASJC Scopus subject areas
- Ageing
- Geriatrics and Gerontology
Cite this
Heterogeneity of Thyroid Function and Impact of Peripheral Thyroxine Deiodination in Centenarians and Semi-Supercentenarians : Association With Functional Status and Mortality. / Ostan, Rita; Monti, Daniela; Mari, Daniela; Arosio, Beatrice; Gentilini, Davide; Ferri, Evelyn; Passarino, Giuseppe; De Rango, Francesco; D'Aquila, Patrizia; Mariotti, Stefano; Pasquali, Renato; Fanelli, Flaminia; Bucci, Laura; Franceschi, Claudio; Vitale, Giovanni.
In: The journals of gerontology. Series A, Biological sciences and medical sciences, Vol. 74, No. 6, 16.05.2019, p. 802-810.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Heterogeneity of Thyroid Function and Impact of Peripheral Thyroxine Deiodination in Centenarians and Semi-Supercentenarians
T2 - Association With Functional Status and Mortality
AU - Ostan, Rita
AU - Monti, Daniela
AU - Mari, Daniela
AU - Arosio, Beatrice
AU - Gentilini, Davide
AU - Ferri, Evelyn
AU - Passarino, Giuseppe
AU - De Rango, Francesco
AU - D'Aquila, Patrizia
AU - Mariotti, Stefano
AU - Pasquali, Renato
AU - Fanelli, Flaminia
AU - Bucci, Laura
AU - Franceschi, Claudio
AU - Vitale, Giovanni
PY - 2019/5/16
Y1 - 2019/5/16
N2 - Thyroid hormones (FT3, FT4) and thyroid-stimulating hormone (TSH) were evaluated in a population of 672 well-characterized Italian subjects (age range: 52-113 years), including an unprecedented number of centenarians, semi-supercentenarians, as well as centenarian's offspring and age-matched elderly (CENT, 105+, CENTOFF, and CTRL, respectively). The results show that FT3 level and FT3/FT4 ratio decrease while FT4 and TSH increase in an age-dependent manner. In CENT/105+, higher FT4 level, and lower FT3/FT4 ratio are associated with an impaired functional status and an increased mortality. A cluster analysis identified three clusters of CENT/105+ based on their FT3, FT4, and TSH levels. Cluster 3, characterized by lower FT3 and TSH and higher FT4, shows the worst health status and the shortest survival. Thus, the age-related changes of thyroid hormones extend to the most advanced age, and CENT/105+ are highly heterogeneous regarding thyroid function. This heterogeneity is related to different health, functional and cognitive status, as well as with survival/mortality in CENT/105+. Finally, we investigated a remarkable number of CENT/105+ showing a thyroid profile suggestive of non-thyroidal illness syndrome (NTIS) (excluded from the previous analysis). NTIS CENT/105+ are characterized by a worse functional and cognitive status and an increased mortality with respect to CENT/105+ without NTIS.
AB - Thyroid hormones (FT3, FT4) and thyroid-stimulating hormone (TSH) were evaluated in a population of 672 well-characterized Italian subjects (age range: 52-113 years), including an unprecedented number of centenarians, semi-supercentenarians, as well as centenarian's offspring and age-matched elderly (CENT, 105+, CENTOFF, and CTRL, respectively). The results show that FT3 level and FT3/FT4 ratio decrease while FT4 and TSH increase in an age-dependent manner. In CENT/105+, higher FT4 level, and lower FT3/FT4 ratio are associated with an impaired functional status and an increased mortality. A cluster analysis identified three clusters of CENT/105+ based on their FT3, FT4, and TSH levels. Cluster 3, characterized by lower FT3 and TSH and higher FT4, shows the worst health status and the shortest survival. Thus, the age-related changes of thyroid hormones extend to the most advanced age, and CENT/105+ are highly heterogeneous regarding thyroid function. This heterogeneity is related to different health, functional and cognitive status, as well as with survival/mortality in CENT/105+. Finally, we investigated a remarkable number of CENT/105+ showing a thyroid profile suggestive of non-thyroidal illness syndrome (NTIS) (excluded from the previous analysis). NTIS CENT/105+ are characterized by a worse functional and cognitive status and an increased mortality with respect to CENT/105+ without NTIS.
KW - Health
KW - Human aging
KW - Longevity
KW - Mortality
KW - Thyroid hormones
UR - http://www.scopus.com/inward/record.url?scp=85058972339&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85058972339&partnerID=8YFLogxK
U2 - 10.1093/gerona/gly194
DO - 10.1093/gerona/gly194
M3 - Article
C2 - 30165411
AN - SCOPUS:85058972339
VL - 74
SP - 802
EP - 810
JO - Journals of Gerontology - Series A Biological Sciences and Medical Sciences
JF - Journals of Gerontology - Series A Biological Sciences and Medical Sciences
SN - 1079-5006
IS - 6
ER -