Heterogeneous response of cardiac sympathetic function to cardiac resynchronization therapy in heart failure documented by 11[C]-hydroxy-ephedrine and PET/CT

Selene Capitanio, Cristina Nanni, Cecilia Marini, Rachele Bonfiglioli, Cristian Martignani, Bassam Dib, Chiara Fuccio, Giuseppe Boriani, Lorena Picori, Stefano Boschi, Silvia Morbelli, Stefano Fanti, Gianmario Sambuceti

Research output: Contribution to journalArticle

Abstract

Introduction: Cardiac resynchronization therapy (CRT) is an accepted treatment in patients with end-stage heart failure. PET permits the absolute quantification of global and regional homogeneity in cardiac sympathetic innervation. We evaluated the variation of cardiac adrenergic activity in patients with idiopathic heart failure (IHF) disease (NYHA III-IV) after CRT using 11C-hydroxyephedrine (HED) PET/CT. Methods: Ten IHF patients (mean age. = 68; range. = 55-81; average left ventricular ejection fraction 26 ± 4%) implanted with a resynchronization device underwent three HED PET/CT studies: PET 1 one week after inactive device implantation; PET 2, one week after PET 1 under stimulated rhythm; PET 3, at 3 months under active CRT. A dedicated software (PMOD 3.4 version) was used to estimate global and regional cardiac uptake of HED through 17 segment polar maps. Results: At baseline, HED uptake was heterogeneously distributed throughout the left ventricle with a variation coefficient of 18 ± 5%. This variable markedly decreased after three months CRT (12 ± 5%, p.

Original languageEnglish
Pages (from-to)858-863
Number of pages6
JournalNuclear Medicine and Biology
Volume42
Issue number11
DOIs
Publication statusPublished - Nov 1 2015

Keywords

  • C-hydroxyephedrine
  • Cardiac resynchronization therapy
  • Heart failure
  • PET/CT
  • Sympathetic innervation

ASJC Scopus subject areas

  • Cancer Research
  • Molecular Medicine
  • Radiology Nuclear Medicine and imaging

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