Heterologous immunity: Immunopathology, autoimmunity and protection during viral infections

Liisa K. Selin, Myriam F. Wlodarczyk, Anke R. Kraft, Siwei Nie, Laurie L. Kenney, Roberto Puzone, Franco Celada

Research output: Contribution to journalArticle

38 Citations (Scopus)

Abstract

Heterologous immunity is a common phenomenon present in all infections. Most of the time it is beneficial, mediating protective immunity, but in some individuals that have the wrong crossreactive response it leads to a cascade of events that result in severe immunopathology. Infections have been associated with autoimmune diseases such as diabetes, multiple sclerosis and lupus erythematosis, but also with unusual autoimmune like pathologies where the immune system appears dysregulated, such as, sarcoidosis, colitis, panniculitis, bronchiolitis obliterans, infectious mononucleosis and even chronic fatigue syndrome. Here we review the evidence that to better understand these autoreactive pathologies it requires an evaluation of how T cells are regulated and evolve during sequential infections with different pathogens under the influence of heterologous immunity.

Original languageEnglish
Pages (from-to)328-347
Number of pages20
JournalAutoimmunity
Volume44
Issue number4
DOIs
Publication statusPublished - Jun 2011

Fingerprint

Heterologous Immunity
Virus Diseases
Autoimmunity
Infection
Pathology
Panniculitis
Bronchiolitis Obliterans
Chronic Fatigue Syndrome
Infectious Mononucleosis
Colitis
Sarcoidosis
Autoimmune Diseases
Multiple Sclerosis
Immune System
Immunity
T-Lymphocytes

Keywords

  • autoimmunity
  • Heterologous immunity
  • immune modeling
  • T-cell cross-reactivity
  • viruses

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

Cite this

Selin, L. K., Wlodarczyk, M. F., Kraft, A. R., Nie, S., Kenney, L. L., Puzone, R., & Celada, F. (2011). Heterologous immunity: Immunopathology, autoimmunity and protection during viral infections. Autoimmunity, 44(4), 328-347. https://doi.org/10.3109/08916934.2011.523277

Heterologous immunity : Immunopathology, autoimmunity and protection during viral infections. / Selin, Liisa K.; Wlodarczyk, Myriam F.; Kraft, Anke R.; Nie, Siwei; Kenney, Laurie L.; Puzone, Roberto; Celada, Franco.

In: Autoimmunity, Vol. 44, No. 4, 06.2011, p. 328-347.

Research output: Contribution to journalArticle

Selin, LK, Wlodarczyk, MF, Kraft, AR, Nie, S, Kenney, LL, Puzone, R & Celada, F 2011, 'Heterologous immunity: Immunopathology, autoimmunity and protection during viral infections', Autoimmunity, vol. 44, no. 4, pp. 328-347. https://doi.org/10.3109/08916934.2011.523277
Selin, Liisa K. ; Wlodarczyk, Myriam F. ; Kraft, Anke R. ; Nie, Siwei ; Kenney, Laurie L. ; Puzone, Roberto ; Celada, Franco. / Heterologous immunity : Immunopathology, autoimmunity and protection during viral infections. In: Autoimmunity. 2011 ; Vol. 44, No. 4. pp. 328-347.
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