Heteronanoparticles by self-Assembly of Doxorubicin and Cyclopamine Conjugates

Gaia Fumagalli, Barbara Stella, Ievgenia Pastushenko, Francesca Ricci, Michael S. Christodoulou, Giovanna Damia, Davide Mazza, Silvia Arpicco, Clelia Giannini, Lavinia Morosi, Franco Dosio, Panagiota A. Sotiropoulou, Daniele Passarella

Research output: Contribution to journalArticlepeer-review

Abstract

The preparation of heteronanoparticles (NPs) with doxorubicin (DOXO) and cyclopamine (CYP) conjugates is presented. Biological evaluation on A431 cell lines confirms the maintenance of the activity of the parental drugs. The in vivo study shows that self-assembled NPs reduce tumor growth and toxicity of chemotherapy.

Original languageEnglish
Pages (from-to)953-957
Number of pages5
JournalACS Medicinal Chemistry Letters
Volume8
Issue number9
DOIs
Publication statusPublished - Jan 1 2017

Keywords

  • cancer
  • cyclopamine
  • doxorubicin
  • drug toxicity
  • Self-assembled-nanoparticles

ASJC Scopus subject areas

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

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