Heteronanoparticles by self-Assembly of Doxorubicin and Cyclopamine Conjugates

G Fumagalli, B Stella, I Pastushenko, F Ricci, MS Christodoulou, G Damia, D Mazza, S Arpicco, Clelia Giannini, L Morosi, Franco Dosio, PA Sotiropoulou, D Passarella

Research output: Contribution to journalArticle

Abstract

The preparation of heteronanoparticles (NPs) with doxorubicin (DOXO) and cyclopamine (CYP) conjugates is presented. Biological evaluation on A431 cell lines confirms the maintenance of the activity of the parental drugs. The in vivo study shows that self-assembled NPs reduce tumor growth and toxicity of chemotherapy.
Original languageEnglish
Pages (from-to)953-957
Number of pages5
JournalACS Medicinal Chemistry Letters
Volume8
Issue number9
DOIs
Publication statusPublished - 2017

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    Fumagalli, G., Stella, B., Pastushenko, I., Ricci, F., Christodoulou, MS., Damia, G., Mazza, D., Arpicco, S., Giannini, C., Morosi, L., Dosio, F., Sotiropoulou, PA., & Passarella, D. (2017). Heteronanoparticles by self-Assembly of Doxorubicin and Cyclopamine Conjugates. ACS Medicinal Chemistry Letters, 8(9), 953-957. https://doi.org/10.1021/acsmedchemlett.7b00262