Heteronuclear J-coupling modulation as an imaging method for nuclei in low concentration

F. De Luca, R. Campanella, A. Bifone, B. Maraviglia

Research output: Contribution to journalArticle


A double-resonance imaging method for nuclei in low concentration is presented. The method utilizes the scalar coupling between the low-concentration spin and an abundant or more sensitive spin species. The spatial position of the low-concentration spin is located by identifying all the abundant spins J-coupled to it. The method was tested on CH2FCH2OH, in which the fluorine played the role of the low-density nucleus. The results show that the fluorine nucleus is spatially localized with a signal-to-noise ratio given by its J-coupled 1H nuclei.

Original languageEnglish
Pages (from-to)554-562
Number of pages9
JournalJournal of Magnetic Resonance (1969)
Issue number3
Publication statusPublished - 1991


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