Hexamethylmelamine distribution in patients with ovarian and other pelvic cancers

M. D'Incalci, P. Farina, C. Sessa, C. Mangioni, S. Garattini

Research output: Contribution to journalArticlepeer-review


The distribution of hexamethylmelamine (HMM) was investigated in surgical biopsies from 12 patients with pelvic cancer who were given an oral dose of 200 mg at 2-24 hours before the operation. The highest concentrations of HMM were found in tissues, such as omentum and subcutaneous tissue, that have a predominant lipidic component. HMM concentrations in the primary tumor were lower than in other tissues and were similar to those in plasma. HMM concentrations in metastases appeared to be higher than in the primary tumor, and in metastases with a diameter

Original languageEnglish
Pages (from-to)231-235
Number of pages5
JournalCancer Treatment Reports
Issue number2
Publication statusPublished - 1982

ASJC Scopus subject areas

  • Cancer Research
  • Oncology


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