Hexamethylmelamine in ovarian cancer resistant to cyclophosphamide and adriamycin

G. Bolis; M. D'Incalci; C. Belloni; C. Mangioni

Hexamethylmelamine in ovarian cancer resistant to cyclophosphamide and adriamycin

G. Bolis, M. D'Incalci, C. Belloni, C. Mangioni

Research output: Contribution to journal › Article › peer-review

Abstract

Thirty-four patients resistant to cyclophosphamide and Adriamycin received hexamethylmelamine at one of two dose regimens: 6 mg/kg/day orally for 21 days every 4 weeks or 8 mg/kg/day orally for 21 days every 6 weeks. Only five patients responded. Tolerance to the drug was, however, satisfactory; nausea, pyrosis, and vomiting were the only frequent side effects. Myelosuppression occurred in only one case.

Original language	English
Pages (from-to)	1375-1377
Number of pages	3
Journal	Cancer Treatment Reports
Volume	63
Issue number	8
Publication status	Published - 1979

ASJC Scopus subject areas

Cancer Research
Oncology

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abstract = "Thirty-four patients resistant to cyclophosphamide and Adriamycin received hexamethylmelamine at one of two dose regimens: 6 mg/kg/day orally for 21 days every 4 weeks or 8 mg/kg/day orally for 21 days every 6 weeks. Only five patients responded. Tolerance to the drug was, however, satisfactory; nausea, pyrosis, and vomiting were the only frequent side effects. Myelosuppression occurred in only one case.",

author = "G. Bolis and M. D'Incalci and C. Belloni and C. Mangioni",

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AU - Mangioni, C.

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N2 - Thirty-four patients resistant to cyclophosphamide and Adriamycin received hexamethylmelamine at one of two dose regimens: 6 mg/kg/day orally for 21 days every 4 weeks or 8 mg/kg/day orally for 21 days every 6 weeks. Only five patients responded. Tolerance to the drug was, however, satisfactory; nausea, pyrosis, and vomiting were the only frequent side effects. Myelosuppression occurred in only one case.

AB - Thirty-four patients resistant to cyclophosphamide and Adriamycin received hexamethylmelamine at one of two dose regimens: 6 mg/kg/day orally for 21 days every 4 weeks or 8 mg/kg/day orally for 21 days every 6 weeks. Only five patients responded. Tolerance to the drug was, however, satisfactory; nausea, pyrosis, and vomiting were the only frequent side effects. Myelosuppression occurred in only one case.

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