HF ultrasound vs PET-CT and telethermography in the diagnosis of in-Transit metastases from melanoma: A prospective study and review of the literature

Francesco Maria Solivetti, Flora Desiderio, Antonino Guerrisi, Antonio Bonadies, Carlo Ludovico Maini, Simona Di Filippo, Valerio D'Orazi, Isabella Sperduti, Aldo Di Carlo

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

Background: Over the past several years the incidence of cutaneous melanoma has rapidly increased. This tumor develops often in-transit metastases that significantly reduce patient survival at 5 years. To improve prognosis and quality of life in patients with melanoma metastases, a mini invasive procedure like electrochemotherapy (ECT) is adopted to remove superficial tissue lesions. To detect the melanoma metastases, high frequency (HF) ultrasound (US) is used. This technique, though, can be time-consuming and it needs an expert operator and a high performing machine. Therefore, we asked whether the US could be replaced or integrated with other less time-consuming techniques such as 18-FDG positron emission tomography/computed tomography (PET-CT) and telethermography (TT). Methods: Fifteen patients (4 males and 11 females - age range: 63-91) affected whit advanced stage melanoma were enrolled. They presented 52 in-transit metastases as detected by the three techniques used, HF-US, PET/CT and TT within 30 days before ECT. Results: All the 52 lesions were detected by HF-US (100%), 24/52 were detected by PET-CT (42,6%) and 15/52 were detected by TT (27,7%). PET-CT reported 3.7% false positives, while no false positive were reported by TT. Conclusions: As US detected 100% lesions, compared to the other two techniques used, US, along with clinical examination, has still to be considered as gold standard in the diagnosis of metastatic lesions. US, associated with an exhaustive anamnesis and accurate clinical examination, cannot be replaced by either PET-CT or TT. When US performing devices and experienced operators are not available, though, it is highly recommended to integrate US with at least one of the other techniques. Under certain circumstances, as in the case of obese and non-collaborating patients or in patients with lymphatic stasis, these techniques should be integrated to obtain exact in-transit metastases evaluation.

Original languageEnglish
JournalJournal of Experimental and Clinical Cancer Research
Volume33
Issue number1
DOIs
Publication statusPublished - 2014

Fingerprint

Melanoma
Prospective Studies
Neoplasm Metastasis
Electrochemotherapy
Quality of Life
Positron Emission Tomography Computed Tomography
Equipment and Supplies
Skin
Survival
Incidence
Neoplasms

Keywords

  • 18F-FDG PET-CT
  • Cutaneous melanoma
  • Electrochemotherapy
  • High frequency-ultrasound
  • In transit-metastases
  • Telethermography

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

HF ultrasound vs PET-CT and telethermography in the diagnosis of in-Transit metastases from melanoma : A prospective study and review of the literature. / Solivetti, Francesco Maria; Desiderio, Flora; Guerrisi, Antonino; Bonadies, Antonio; Maini, Carlo Ludovico; Filippo, Simona Di; D'Orazi, Valerio; Sperduti, Isabella; Carlo, Aldo Di.

In: Journal of Experimental and Clinical Cancer Research, Vol. 33, No. 1, 2014.

Research output: Contribution to journalArticle

Solivetti, Francesco Maria ; Desiderio, Flora ; Guerrisi, Antonino ; Bonadies, Antonio ; Maini, Carlo Ludovico ; Filippo, Simona Di ; D'Orazi, Valerio ; Sperduti, Isabella ; Carlo, Aldo Di. / HF ultrasound vs PET-CT and telethermography in the diagnosis of in-Transit metastases from melanoma : A prospective study and review of the literature. In: Journal of Experimental and Clinical Cancer Research. 2014 ; Vol. 33, No. 1.
@article{55e97a0358f24e1e9bfd36f5f74e9655,
title = "HF ultrasound vs PET-CT and telethermography in the diagnosis of in-Transit metastases from melanoma: A prospective study and review of the literature",
abstract = "Background: Over the past several years the incidence of cutaneous melanoma has rapidly increased. This tumor develops often in-transit metastases that significantly reduce patient survival at 5 years. To improve prognosis and quality of life in patients with melanoma metastases, a mini invasive procedure like electrochemotherapy (ECT) is adopted to remove superficial tissue lesions. To detect the melanoma metastases, high frequency (HF) ultrasound (US) is used. This technique, though, can be time-consuming and it needs an expert operator and a high performing machine. Therefore, we asked whether the US could be replaced or integrated with other less time-consuming techniques such as 18-FDG positron emission tomography/computed tomography (PET-CT) and telethermography (TT). Methods: Fifteen patients (4 males and 11 females - age range: 63-91) affected whit advanced stage melanoma were enrolled. They presented 52 in-transit metastases as detected by the three techniques used, HF-US, PET/CT and TT within 30 days before ECT. Results: All the 52 lesions were detected by HF-US (100{\%}), 24/52 were detected by PET-CT (42,6{\%}) and 15/52 were detected by TT (27,7{\%}). PET-CT reported 3.7{\%} false positives, while no false positive were reported by TT. Conclusions: As US detected 100{\%} lesions, compared to the other two techniques used, US, along with clinical examination, has still to be considered as gold standard in the diagnosis of metastatic lesions. US, associated with an exhaustive anamnesis and accurate clinical examination, cannot be replaced by either PET-CT or TT. When US performing devices and experienced operators are not available, though, it is highly recommended to integrate US with at least one of the other techniques. Under certain circumstances, as in the case of obese and non-collaborating patients or in patients with lymphatic stasis, these techniques should be integrated to obtain exact in-transit metastases evaluation.",
keywords = "18F-FDG PET-CT, Cutaneous melanoma, Electrochemotherapy, High frequency-ultrasound, In transit-metastases, Telethermography",
author = "Solivetti, {Francesco Maria} and Flora Desiderio and Antonino Guerrisi and Antonio Bonadies and Maini, {Carlo Ludovico} and Filippo, {Simona Di} and Valerio D'Orazi and Isabella Sperduti and Carlo, {Aldo Di}",
year = "2014",
doi = "10.1186/s13046-014-0096-3",
language = "English",
volume = "33",
journal = "Journal of Experimental and Clinical Cancer Research",
issn = "0392-9078",
publisher = "BioMed Central Ltd.",
number = "1",

}

TY - JOUR

T1 - HF ultrasound vs PET-CT and telethermography in the diagnosis of in-Transit metastases from melanoma

T2 - A prospective study and review of the literature

AU - Solivetti, Francesco Maria

AU - Desiderio, Flora

AU - Guerrisi, Antonino

AU - Bonadies, Antonio

AU - Maini, Carlo Ludovico

AU - Filippo, Simona Di

AU - D'Orazi, Valerio

AU - Sperduti, Isabella

AU - Carlo, Aldo Di

PY - 2014

Y1 - 2014

N2 - Background: Over the past several years the incidence of cutaneous melanoma has rapidly increased. This tumor develops often in-transit metastases that significantly reduce patient survival at 5 years. To improve prognosis and quality of life in patients with melanoma metastases, a mini invasive procedure like electrochemotherapy (ECT) is adopted to remove superficial tissue lesions. To detect the melanoma metastases, high frequency (HF) ultrasound (US) is used. This technique, though, can be time-consuming and it needs an expert operator and a high performing machine. Therefore, we asked whether the US could be replaced or integrated with other less time-consuming techniques such as 18-FDG positron emission tomography/computed tomography (PET-CT) and telethermography (TT). Methods: Fifteen patients (4 males and 11 females - age range: 63-91) affected whit advanced stage melanoma were enrolled. They presented 52 in-transit metastases as detected by the three techniques used, HF-US, PET/CT and TT within 30 days before ECT. Results: All the 52 lesions were detected by HF-US (100%), 24/52 were detected by PET-CT (42,6%) and 15/52 were detected by TT (27,7%). PET-CT reported 3.7% false positives, while no false positive were reported by TT. Conclusions: As US detected 100% lesions, compared to the other two techniques used, US, along with clinical examination, has still to be considered as gold standard in the diagnosis of metastatic lesions. US, associated with an exhaustive anamnesis and accurate clinical examination, cannot be replaced by either PET-CT or TT. When US performing devices and experienced operators are not available, though, it is highly recommended to integrate US with at least one of the other techniques. Under certain circumstances, as in the case of obese and non-collaborating patients or in patients with lymphatic stasis, these techniques should be integrated to obtain exact in-transit metastases evaluation.

AB - Background: Over the past several years the incidence of cutaneous melanoma has rapidly increased. This tumor develops often in-transit metastases that significantly reduce patient survival at 5 years. To improve prognosis and quality of life in patients with melanoma metastases, a mini invasive procedure like electrochemotherapy (ECT) is adopted to remove superficial tissue lesions. To detect the melanoma metastases, high frequency (HF) ultrasound (US) is used. This technique, though, can be time-consuming and it needs an expert operator and a high performing machine. Therefore, we asked whether the US could be replaced or integrated with other less time-consuming techniques such as 18-FDG positron emission tomography/computed tomography (PET-CT) and telethermography (TT). Methods: Fifteen patients (4 males and 11 females - age range: 63-91) affected whit advanced stage melanoma were enrolled. They presented 52 in-transit metastases as detected by the three techniques used, HF-US, PET/CT and TT within 30 days before ECT. Results: All the 52 lesions were detected by HF-US (100%), 24/52 were detected by PET-CT (42,6%) and 15/52 were detected by TT (27,7%). PET-CT reported 3.7% false positives, while no false positive were reported by TT. Conclusions: As US detected 100% lesions, compared to the other two techniques used, US, along with clinical examination, has still to be considered as gold standard in the diagnosis of metastatic lesions. US, associated with an exhaustive anamnesis and accurate clinical examination, cannot be replaced by either PET-CT or TT. When US performing devices and experienced operators are not available, though, it is highly recommended to integrate US with at least one of the other techniques. Under certain circumstances, as in the case of obese and non-collaborating patients or in patients with lymphatic stasis, these techniques should be integrated to obtain exact in-transit metastases evaluation.

KW - 18F-FDG PET-CT

KW - Cutaneous melanoma

KW - Electrochemotherapy

KW - High frequency-ultrasound

KW - In transit-metastases

KW - Telethermography

UR - http://www.scopus.com/inward/record.url?scp=84928535105&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84928535105&partnerID=8YFLogxK

U2 - 10.1186/s13046-014-0096-3

DO - 10.1186/s13046-014-0096-3

M3 - Article

C2 - 25420445

AN - SCOPUS:84928535105

VL - 33

JO - Journal of Experimental and Clinical Cancer Research

JF - Journal of Experimental and Clinical Cancer Research

SN - 0392-9078

IS - 1

ER -