HHV-6 infection of tonsils and adenoids in children with hypertrophy and upper airway recurrent infections

Manola Comar; Domenico Grasso; Gianna dal Molin; Elisabetta Zocconi; Cesare Campello

doi:10.1016/j.ijporl.2009.10.008

HHV-6 infection of tonsils and adenoids in children with hypertrophy and upper airway recurrent infections

Manola Comar, Domenico Grasso, Gianna dal Molin, Elisabetta Zocconi, Cesare Campello

IRCCS pediatrico Burlo Garofolo

Research output: Contribution to journal › Article › peer-review

Abstract

Objective: Human herpes virus 6 (HHV-6), the agent of a self-limiting exanthematic disease in childhood, persists in a silent state in the secondary lymphoid organs and the reactivation is characterized by HHV-6-induced inflammatory cytokines. This study investigates the possible etiological role of HHV-6 in children affected by tonsil and adenoid hypertrophy. Methods: 55 tonsils, 80 adenoids fresh tissues and 74 blood samples were collected from 80 children (mean age 4.8 years, 43.5% female) undergoing elective tonsillectomy and/or adenoidectomy for tissue hypertrophy. Moreover, patients with 6 cells suggesting a latent/persistent phase of infection. Conclusion: These results reinforce the role of the secondary lymphoid organs as an important reservoir for HHV-6B. Nevertheless, infection of lymphoid cells, sustained by a low level of replication, could be sufficient to increase the local injury through an autologous mechanism of inflammation.

Original language	English
Pages (from-to)	47-49
Number of pages	3
Journal	International Journal of Pediatric Otorhinolaryngology
Volume	74
Issue number	1
DOIs	https://doi.org/10.1016/j.ijporl.2009.10.008
Publication status	Published - Jan 2010

Keywords

Adenoids
Children
HHV-6
Hypertrophy
Tonsils

ASJC Scopus subject areas

Otorhinolaryngology
Pediatrics, Perinatology, and Child Health

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10.1016/j.ijporl.2009.10.008

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title = "HHV-6 infection of tonsils and adenoids in children with hypertrophy and upper airway recurrent infections",

abstract = "Objective: Human herpes virus 6 (HHV-6), the agent of a self-limiting exanthematic disease in childhood, persists in a silent state in the secondary lymphoid organs and the reactivation is characterized by HHV-6-induced inflammatory cytokines. This study investigates the possible etiological role of HHV-6 in children affected by tonsil and adenoid hypertrophy. Methods: 55 tonsils, 80 adenoids fresh tissues and 74 blood samples were collected from 80 children (mean age 4.8 years, 43.5% female) undergoing elective tonsillectomy and/or adenoidectomy for tissue hypertrophy. Moreover, patients with 6 cells suggesting a latent/persistent phase of infection. Conclusion: These results reinforce the role of the secondary lymphoid organs as an important reservoir for HHV-6B. Nevertheless, infection of lymphoid cells, sustained by a low level of replication, could be sufficient to increase the local injury through an autologous mechanism of inflammation.",

keywords = "Adenoids, Children, HHV-6, Hypertrophy, Tonsils",

author = "Manola Comar and Domenico Grasso and {dal Molin}, Gianna and Elisabetta Zocconi and Cesare Campello",

year = "2010",

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doi = "10.1016/j.ijporl.2009.10.008",

language = "English",

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pages = "47--49",

journal = "International Journal of Pediatric Otorhinolaryngology",

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T1 - HHV-6 infection of tonsils and adenoids in children with hypertrophy and upper airway recurrent infections

AU - Comar, Manola

AU - Grasso, Domenico

AU - dal Molin, Gianna

AU - Zocconi, Elisabetta

AU - Campello, Cesare

PY - 2010/1

Y1 - 2010/1

N2 - Objective: Human herpes virus 6 (HHV-6), the agent of a self-limiting exanthematic disease in childhood, persists in a silent state in the secondary lymphoid organs and the reactivation is characterized by HHV-6-induced inflammatory cytokines. This study investigates the possible etiological role of HHV-6 in children affected by tonsil and adenoid hypertrophy. Methods: 55 tonsils, 80 adenoids fresh tissues and 74 blood samples were collected from 80 children (mean age 4.8 years, 43.5% female) undergoing elective tonsillectomy and/or adenoidectomy for tissue hypertrophy. Moreover, patients with 6 cells suggesting a latent/persistent phase of infection. Conclusion: These results reinforce the role of the secondary lymphoid organs as an important reservoir for HHV-6B. Nevertheless, infection of lymphoid cells, sustained by a low level of replication, could be sufficient to increase the local injury through an autologous mechanism of inflammation.

AB - Objective: Human herpes virus 6 (HHV-6), the agent of a self-limiting exanthematic disease in childhood, persists in a silent state in the secondary lymphoid organs and the reactivation is characterized by HHV-6-induced inflammatory cytokines. This study investigates the possible etiological role of HHV-6 in children affected by tonsil and adenoid hypertrophy. Methods: 55 tonsils, 80 adenoids fresh tissues and 74 blood samples were collected from 80 children (mean age 4.8 years, 43.5% female) undergoing elective tonsillectomy and/or adenoidectomy for tissue hypertrophy. Moreover, patients with 6 cells suggesting a latent/persistent phase of infection. Conclusion: These results reinforce the role of the secondary lymphoid organs as an important reservoir for HHV-6B. Nevertheless, infection of lymphoid cells, sustained by a low level of replication, could be sufficient to increase the local injury through an autologous mechanism of inflammation.

KW - Adenoids

KW - Children

KW - HHV-6

KW - Hypertrophy

KW - Tonsils

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HHV-6 infection of tonsils and adenoids in children with hypertrophy and upper airway recurrent infections

Abstract

Keywords

ASJC Scopus subject areas

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