HHV-6A infection dysregulates autophagy/UPR interplay increasing beta amyloid production and tau phosphorylation in astrocytoma cells as well as in primary neurons, possible molecular mechanisms linking viral infection to Alzheimer's disease

Maria Anele Romeo, Maria Saveria Gilardini Montani, Aurelia Gaeta, Gabriella D'Orazi, Alberto Faggioni, Mara Cirone

Research output: Contribution to journal › Article

Abstract

HHV-6A and HHV-6B are neurotropic viruses able to dysregulate autophagy and activate ER stress/UPR in several cell types. The appropriate functioning of these processes is required for cell homeostasis, particularly in post-mitotic cells such as neuronal cells. Interestingly, neurodegenerative diseases such as Alzheimer's disease (AD) are often accompanied by autophagy dysregulation and abnormal UPR activation. This study demonstrated for the first time that HHV-6A infection of astrocytoma cells and primary neurons reduces autophagy, increases Aβ production and activates ER stress/UPR promoting tau protein hyper-phosphorylation. Our results support previous studies suggesting that HHV-6A infection may play a role in AD and unveil the possible underlying molecular mechanisms involved.

Original languageEnglish
Article number165647
JournalBiochimica et Biophysica Acta - Molecular Basis of Disease
Volume1866
Issue number3
DOIs
Publication statusPublished - Mar 1 2020

Keywords

  • Alzheimer's disease
  • Autophagy/UPR
  • Aβ
  • HHV-6A
  • Neurons
  • Tau phosphorylation

ASJC Scopus subject areas

  • Molecular Medicine
  • Molecular Biology

Cite this

HHV-6A infection dysregulates autophagy/UPR interplay increasing beta amyloid production and tau phosphorylation in astrocytoma cells as well as in primary neurons, possible molecular mechanisms linking viral infection to Alzheimer's disease. / Romeo, Maria Anele; Gilardini Montani, Maria Saveria; Gaeta, Aurelia; D'Orazi, Gabriella; Faggioni, Alberto; Cirone, Mara.

In: Biochimica et Biophysica Acta - Molecular Basis of Disease, Vol. 1866, No. 3, 165647, 01.03.2020.

Research output: Contribution to journal › Article

Romeo, MA, Gilardini Montani, MS, Gaeta, A, D'Orazi, G, Faggioni, A & Cirone, M 2020, 'HHV-6A infection dysregulates autophagy/UPR interplay increasing beta amyloid production and tau phosphorylation in astrocytoma cells as well as in primary neurons, possible molecular mechanisms linking viral infection to Alzheimer's disease', Biochimica et Biophysica Acta - Molecular Basis of Disease, vol. 1866, no. 3, 165647. https://doi.org/10.1016/j.bbadis.2019.165647
Romeo MA, Gilardini Montani MS, Gaeta A, D'Orazi G, Faggioni A, Cirone M. HHV-6A infection dysregulates autophagy/UPR interplay increasing beta amyloid production and tau phosphorylation in astrocytoma cells as well as in primary neurons, possible molecular mechanisms linking viral infection to Alzheimer's disease. Biochimica et Biophysica Acta - Molecular Basis of Disease. 2020 Mar 1;1866(3). 165647. https://doi.org/10.1016/j.bbadis.2019.165647
Romeo, Maria Anele ; Gilardini Montani, Maria Saveria ; Gaeta, Aurelia ; D'Orazi, Gabriella ; Faggioni, Alberto ; Cirone, Mara. / HHV-6A infection dysregulates autophagy/UPR interplay increasing beta amyloid production and tau phosphorylation in astrocytoma cells as well as in primary neurons, possible molecular mechanisms linking viral infection to Alzheimer's disease. In: Biochimica et Biophysica Acta - Molecular Basis of Disease. 2020 ; Vol. 1866, No. 3.
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AU - Gaeta, Aurelia

AU - D'Orazi, Gabriella

AU - Faggioni, Alberto

AU - Cirone, Mara

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