HHV-8-associated lymphoma: State-of-the-art review

Antonino Carbone, Annunziata Gloghini

Research output: Contribution to journalArticle


During the first decade after the discovery of primary effusion lymphoma (PEL), sporadic and serial reports suggested that Kaposi-sarcoma-associated- herpesvirus/human-herpesvirus-8 (KSHV/HHV-8)-associated lymphomas in their liquid and solid presentation are clinically distinct, representing part of the spectrum of PEL. In HIV-seropositive patients with serous effusions, these solid lymphomas were reported before the development of an effusion lymphoma and following resolution of PEL. More recently, solid lymphomas not associated with lymphomatous effusion have been found in HIV-seropositive and HIV-seronegative patients. Despite the diversification in the clinical presentation of KSHV/HHV-8-associated lymphomas, most cases demonstrated a similar morphology, immunophenotype and KSHV/HHV-8 viral status.

Original languageEnglish
Pages (from-to)129-131
Number of pages3
JournalActa Haematologica
Issue number3
Publication statusPublished - Mar 2007


  • Human herpesvirus 8
  • Kaposi-sarcoma-associated herpesvirus
  • Primary effusion lymphoma

ASJC Scopus subject areas

  • Hematology

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