HIBISCUS

Hydroxychloroquine for the secondary prevention of thrombotic and obstetrical events in primary antiphospholipid syndrome

Cristina Belizna, Francesca Pregnolato, Sebastien Abad, Jaume Alijotas-Reig, Howard Amital, Zahir Amoura, Laura Andreoli, Emmanuel Andres, Achile Aouba, Sule Apras Bilgen, Laurent Arnaud, Boris Bienvenu, Viktoria Bitsadze, Patrick Blanco, Miri Blank, Maria Orietta Borghi, Antonia Caligaro, Elisabeta Candrea, Valentina Canti, Laurent Chiche & 30 others Jean Marie Chretien, Jan Willem Cohen Tervaert, Laura Damian, Teresa Delross, Emmanuelle Dernis, Katrien Devreese, Aleksandra Djokovic, Enrique Esteve-Valverde, Maria Favaro, Céline Fassot, Raquel Ferrer-Oliveras, Alban Godon, Mohamed Hamidou, Milena Hasan, Daniel Henrion, Bernard Imbert, Pierre Yves Jeandel, Pascale Jeannin, Patrick Jego, Noemie Jourde-Chiche, Jamilya Khizroeva, Olivier Lambotte, Cédric Landron, Jose Omar Latino, Estibaliz Lazaro, Karina de Leeuw, Thomas Le Gallou, Levent Kiliç, Maarten Limper, Pier Luigi Meroni

Research output: Contribution to journalReview article

4 Citations (Scopus)

Abstract

The relapse rate in antiphospholipid syndrome (APS) remains high, i.e. around 20%–21% at 5 years in thrombotic APS and 20–28% in obstetrical APS [2, 3]. Hydroxychloroquine (HCQ) appears as an additional therapy, as it possesses immunomodulatory and anti-thrombotic various effects [4–16]. Our group recently obtained the orphan designation of HCQ in antiphospholipid syndrome by the European Medicine Agency. Furthermore, the leaders of the project made the proposal of an international project, HIBISCUS, about the use of Hydroxychloroquine in secondary prevention of obstetrical and thrombotic events in primary APS. This study has been launched in several countries and at now, 53 centers from 16 countries participate to this international trial. This trial consists in two parts: a retrospective and a prospective study. The French part of the trial in thrombosis has been granted by the French Minister of Health in December 2015 (the academic trial independent of the pharmaceutical industry PHRC N PAPIRUS) and is coordinated by one of the members of the leading consortium of HIBISCUS.

Original languageEnglish
Pages (from-to)1153-1168
Number of pages16
JournalAutoimmunity Reviews
Volume17
Issue number12
DOIs
Publication statusPublished - Dec 1 2018

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Hydroxychloroquine
Antiphospholipid Syndrome
Secondary Prevention
Drug Industry
Thrombosis
Medicine
Prospective Studies
Recurrence
Health

Keywords

  • Antiphospholipid syndrome
  • Hydroxychloroquine
  • Primary antiphospholipid syndrome
  • Secondary prevention

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

Cite this

HIBISCUS : Hydroxychloroquine for the secondary prevention of thrombotic and obstetrical events in primary antiphospholipid syndrome. / Belizna, Cristina; Pregnolato, Francesca; Abad, Sebastien; Alijotas-Reig, Jaume; Amital, Howard; Amoura, Zahir; Andreoli, Laura; Andres, Emmanuel; Aouba, Achile; Apras Bilgen, Sule; Arnaud, Laurent; Bienvenu, Boris; Bitsadze, Viktoria; Blanco, Patrick; Blank, Miri; Borghi, Maria Orietta; Caligaro, Antonia; Candrea, Elisabeta; Canti, Valentina; Chiche, Laurent; Chretien, Jean Marie; Cohen Tervaert, Jan Willem; Damian, Laura; Delross, Teresa; Dernis, Emmanuelle; Devreese, Katrien; Djokovic, Aleksandra; Esteve-Valverde, Enrique; Favaro, Maria; Fassot, Céline; Ferrer-Oliveras, Raquel; Godon, Alban; Hamidou, Mohamed; Hasan, Milena; Henrion, Daniel; Imbert, Bernard; Jeandel, Pierre Yves; Jeannin, Pascale; Jego, Patrick; Jourde-Chiche, Noemie; Khizroeva, Jamilya; Lambotte, Olivier; Landron, Cédric; Latino, Jose Omar; Lazaro, Estibaliz; de Leeuw, Karina; Le Gallou, Thomas; Kiliç, Levent; Limper, Maarten; Meroni, Pier Luigi.

In: Autoimmunity Reviews, Vol. 17, No. 12, 01.12.2018, p. 1153-1168.

Research output: Contribution to journalReview article

Belizna, C, Pregnolato, F, Abad, S, Alijotas-Reig, J, Amital, H, Amoura, Z, Andreoli, L, Andres, E, Aouba, A, Apras Bilgen, S, Arnaud, L, Bienvenu, B, Bitsadze, V, Blanco, P, Blank, M, Borghi, MO, Caligaro, A, Candrea, E, Canti, V, Chiche, L, Chretien, JM, Cohen Tervaert, JW, Damian, L, Delross, T, Dernis, E, Devreese, K, Djokovic, A, Esteve-Valverde, E, Favaro, M, Fassot, C, Ferrer-Oliveras, R, Godon, A, Hamidou, M, Hasan, M, Henrion, D, Imbert, B, Jeandel, PY, Jeannin, P, Jego, P, Jourde-Chiche, N, Khizroeva, J, Lambotte, O, Landron, C, Latino, JO, Lazaro, E, de Leeuw, K, Le Gallou, T, Kiliç, L, Limper, M & Meroni, PL 2018, 'HIBISCUS: Hydroxychloroquine for the secondary prevention of thrombotic and obstetrical events in primary antiphospholipid syndrome', Autoimmunity Reviews, vol. 17, no. 12, pp. 1153-1168. https://doi.org/10.1016/j.autrev.2018.05.012
Belizna, Cristina ; Pregnolato, Francesca ; Abad, Sebastien ; Alijotas-Reig, Jaume ; Amital, Howard ; Amoura, Zahir ; Andreoli, Laura ; Andres, Emmanuel ; Aouba, Achile ; Apras Bilgen, Sule ; Arnaud, Laurent ; Bienvenu, Boris ; Bitsadze, Viktoria ; Blanco, Patrick ; Blank, Miri ; Borghi, Maria Orietta ; Caligaro, Antonia ; Candrea, Elisabeta ; Canti, Valentina ; Chiche, Laurent ; Chretien, Jean Marie ; Cohen Tervaert, Jan Willem ; Damian, Laura ; Delross, Teresa ; Dernis, Emmanuelle ; Devreese, Katrien ; Djokovic, Aleksandra ; Esteve-Valverde, Enrique ; Favaro, Maria ; Fassot, Céline ; Ferrer-Oliveras, Raquel ; Godon, Alban ; Hamidou, Mohamed ; Hasan, Milena ; Henrion, Daniel ; Imbert, Bernard ; Jeandel, Pierre Yves ; Jeannin, Pascale ; Jego, Patrick ; Jourde-Chiche, Noemie ; Khizroeva, Jamilya ; Lambotte, Olivier ; Landron, Cédric ; Latino, Jose Omar ; Lazaro, Estibaliz ; de Leeuw, Karina ; Le Gallou, Thomas ; Kiliç, Levent ; Limper, Maarten ; Meroni, Pier Luigi. / HIBISCUS : Hydroxychloroquine for the secondary prevention of thrombotic and obstetrical events in primary antiphospholipid syndrome. In: Autoimmunity Reviews. 2018 ; Vol. 17, No. 12. pp. 1153-1168.
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AU - Abad, Sebastien

AU - Alijotas-Reig, Jaume

AU - Amital, Howard

AU - Amoura, Zahir

AU - Andreoli, Laura

AU - Andres, Emmanuel

AU - Aouba, Achile

AU - Apras Bilgen, Sule

AU - Arnaud, Laurent

AU - Bienvenu, Boris

AU - Bitsadze, Viktoria

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AU - Blank, Miri

AU - Borghi, Maria Orietta

AU - Caligaro, Antonia

AU - Candrea, Elisabeta

AU - Canti, Valentina

AU - Chiche, Laurent

AU - Chretien, Jean Marie

AU - Cohen Tervaert, Jan Willem

AU - Damian, Laura

AU - Delross, Teresa

AU - Dernis, Emmanuelle

AU - Devreese, Katrien

AU - Djokovic, Aleksandra

AU - Esteve-Valverde, Enrique

AU - Favaro, Maria

AU - Fassot, Céline

AU - Ferrer-Oliveras, Raquel

AU - Godon, Alban

AU - Hamidou, Mohamed

AU - Hasan, Milena

AU - Henrion, Daniel

AU - Imbert, Bernard

AU - Jeandel, Pierre Yves

AU - Jeannin, Pascale

AU - Jego, Patrick

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AU - Lambotte, Olivier

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AU - Latino, Jose Omar

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AU - de Leeuw, Karina

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