HIC gene, a candidate suppressor gene within a minimal region of loss at 7q31.1 in myeloid neoplasms

Daniela Cigognini, Gianmarco Corneo, Elisa Fermo, Alberto Zanella, Pasquale Tripputi

Research output: Contribution to journalArticle

Abstract

We studied monosomy and deletions of chromosome 7 in 170 patients with myeloid disorders and we identified a minimal region of loss in 7q31.1 spanning between the D7S2554 and D7S2460 markers. The closest gene to our most deleted microsatellite, D7S2554, is the human I-mfa domain containing (HIC) gene, alias MyoD family inhibitor domain containing (MDFIC). We investigated the involvement of HIC in myeloid neoplasms by screening for mutations the coding regions and the intron-exon boundaries of this gene in 15 patients who presented chromosome 7 deletions in the region of HIC. No mutations were found in the coding region of this gene.

Original languageEnglish
Pages (from-to)477-482
Number of pages6
JournalLeukemia Research
Volume31
Issue number4
DOIs
Publication statusPublished - Apr 2007

Keywords

  • Acute myeloid leukemia
  • Chromosome 7
  • Deletion
  • DNA
  • Human I-mfa domain-containing protein
  • MDFIC
  • Myelodysplasia

ASJC Scopus subject areas

  • Cancer Research
  • Hematology
  • Oncology

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