HIFU for Bone Metastases and other Musculoskeletal Applications

Roberto Scipione, Michele Anzidei, Alberto Bazzocchi, Cesare Gagliardo, Carlo Catalano, Alessandro Napoli

Research output: Contribution to journalReview articlepeer-review


High-intensity focused ultrasound (HIFU) is a totally noninvasive procedure that has shown promising results in the management of numerous malignant and nonmalignant conditions. Under magnetic resonance or ultrasound guidance, high-intensity ultrasound waves are focused on a small, well-defined target region, inducing biologic tissue heating and coagulative necrosis, thus resulting in a precise and localized ablation. This treatment has shown both great safety and efficacy profiles, and may offer a multimodal approach to different diseases, providing pain palliation, potential local tumor control, and, in some cases, remineralization of trabecular bone. In musculoskeletal field, HIFU received FDA approval for treating bone metastasis, but its application has also been extended to other conditions, such as osteoid osteoma, desmoid tumor, low-flow vascular malformation, and facet joint osteoarthritis. This article illustrates the basic principles of HIFU and its main effects on biologic tissues with particular attention on bone, provides a step-by-step description of the HIFU procedure, and discusses the commonly treated conditions, in particular bone metastases.

Original languageEnglish
Pages (from-to)261-267
Number of pages7
JournalSeminars in Interventional Radiology
Issue number4
Publication statusPublished - Oct 2018


  • High-intensity focused ultrasound
  • bone metastases
  • interventional radiology
  • osteoid osteoma
  • pain palliation


Dive into the research topics of 'HIFU for Bone Metastases and other Musculoskeletal Applications'. Together they form a unique fingerprint.

Cite this