High 99mTc-DPD myocardial uptake in a patient with apolipoprotein AI-related amyloidotic cardiomyopathy

Candida Cristina Quarta, Laura Obici, Pier Luigi Guidalotti, Maurizio Pieroni, Simone Longhi, Stefano Perlini, Laura Verga, Giampaolo Merlini, Claudio Rapezzi

Research output: Contribution to journalArticlepeer-review


Amyloidotic cardiomyopathy is still a widely underdiagnosed condition that usually requires endomyocardial biopsy (EMB) for a definite diagnosis. 99mTc-3,3-diphosphono-1,2-propanodicarboxylic acid ( 99mTc-DPD) has proven highly sensitive for detecting amyloidotic cardiomyopathy due to transthyretin-related amyloid deposition. Herein we report the first description of the 99mTc-DPD scintigraphy profile in a patient with suspected amyloidotic cardiomyopathy and a final EMB- and genetically-proven diagnosis of familial apolipoprotein AI amyloidosis due to Leu174Ser variant. Abbreviations: AL: light-chain associated amyloidosis; ApoAI: apolipoprotein AI; ATTR: hereditary transthyretin-related amyloidosis; EMB: endomyocardial biopsy; HCM: hypertrophic cardiomyopathy; HR: heart retention; H/WB: heart/whole-body retention ratio; LV: left ventricular; SPECT: single-photon emission computed tomography; SSA: senile systemic amyloidosis; 99mTc-DPD: 99mTc-3,3-diphosphono-1,2-propanodicarboxylic acid; TDI: tissue Doppler imaging; TTR: transthyretin.

Original languageEnglish
Pages (from-to)48-51
Number of pages4
Issue number1
Publication statusPublished - Mar 2013


  • Tc-DPD scintigraphy
  • Amyloidotic cardiomyopathy
  • Apolipoprotein AI
  • Familial amyloidosis

ASJC Scopus subject areas

  • Internal Medicine
  • Medicine(all)


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