High-affinity monomeric 67-kD laminin receptors and prognosis in pancreatic endocrine tumours

Giuseppe Pelosi, Felice Pasini, Enrica Bresaola, Giuseppe Bogina, Paolo Pederzoli, Sonia Biolo, Sylvie Menard, Giuseppe Zamboni

Research output: Contribution to journalArticlepeer-review

Abstract

Cell-surface high-affinity monomeric 67-kD laminin receptors have been proposed to promote the invasion and metastasis of a variety of tumours, but there are, as yet, no data regarding the expression of these molecules in pancreatic endocrine tumours (PETs). The prognosis of these very rare tumours is problematic and the only irrefutable evidence of their malignancy still continues to be the occurrence of local invasion and metastases. In this retrospective investigation, 34 functioning and 48 non-functioning sporadic PETs were evaluated for the expression of the MLuC5 monoclonal antibody, which specifically recognizes the 67-kD laminin receptors. Laminin receptors were found in 42/82 cases (51 per cent) and their expression was associated with metastatic disease (P

Original languageEnglish
Pages (from-to)62-69
Number of pages8
JournalJournal of Pathology
Volume183
Issue number1
DOIs
Publication statusPublished - Sep 1997

Keywords

  • 67-kD laminin receptor
  • Endocrine tumours
  • Metastases
  • Pancreas
  • Prognosis
  • Survival

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

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