High aminopeptidase N/CD13 levels characterize human amniotic mesenchymal stem cells and drive their increased adipogenic potential in obese women

Laura Iaffaldano, Carmela Nardelli, Maddalena Raia, Elisabetta Mariotti, Maddalena Ferrigno, Filomena Quaglia, Giuseppe Labruna, Valentina Capobianco, Angela Capone, Giuseppe Maria Maruotti, Lucio Pastore, Rosa Di Noto, Pasquale Martinelli, Lucia Sacchetti, Luigi Del Vecchio

Research output: Contribution to journalArticlepeer-review

Abstract

Maternal obesity is associated to increased fetal risk of obesity and other metabolic diseases. Human amniotic mesenchymal stem cells (hA-MSCs) have not been characterized in obese women. The aim of this study was to isolate and compare hA-MSC immunophenotypes from obese (Ob-) and normal weight control (Co-) women, to identify alterations possibly predisposing the fetus to obesity. We enrolled 16 Ob- and 7 Co-women at delivery (mean/SEM prepregnancy body mass index: 40.3/1.8 and 22.4/1.0 kg/m2, respectively), and 32 not pregnant women. hA-MSCs were phenotyped by flow cytometry; several maternal and newborn clinical and biochemical parameters were also measured. The expression of membrane antigen CD13 was higher on Ob-hA-MSCs than on Co-hA-MSCs (P=0.005). Also, serum levels of CD13 at delivery were higher in Ob- versus Co-pregnant women and correlated with CD13 antigen expression on Ob-hA-MSCs (r 2=0.84, P

Original languageEnglish
Pages (from-to)2287-2297
Number of pages11
JournalStem Cells and Development
Volume22
Issue number16
DOIs
Publication statusPublished - Aug 15 2013

ASJC Scopus subject areas

  • Cell Biology
  • Developmental Biology
  • Hematology

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