Abstract
Early mortality is high in hemodialysis (HD) patients, but little is known about early cardiovascular event (CVE) rates after HD initiation. To study this we analyzed data in the AROii cohort of incident HD patients from over 300 European Fresenius Medical Care dialysis centers. Weekly rates of a composite of CVEs during the first year and monthly rates of the composite and its constituents (coronary artery, cerebrovascular, peripheral arterial, congestive heart failure, and sudden cardiac death) during the first 2 years after HD initiation were assessed. Of 6308 patients that started dialysis within 7 days, 1449 patients experienced 2405 CVEs over the next 2 years. The first-year CVE rate (30.2/100 person-years; 95% CI, 28.7-31.7) greatly exceeded the second-year rate (19.4/100; 95% CI, 18.1-20.8). Composite CVEs were highest during the first week with increased risk compared with the second year, persisting until the fifth month. Except for sudden cardiac death, temporal patterns of rates for all CVE categories were very similar, with highest rates during the first month and a high-risk period extending to 4 months. Higher or lower cumulative weekly dialysis dose, lower blood flow, and lower net ultrafiltration during dialysis were associated with CVE during the high-risk period, but not during the post high-risk period. Thus, the incidence of CVE in the first weeks after HD initiation is much higher than during subsequent periods which raises concerns that HD initiation may trigger CVEs.
| Original language | English |
|---|---|
| Pages (from-to) | 1117-1125 |
| Number of pages | 9 |
| Journal | Kidney International |
| Volume | 88 |
| Issue number | 5 |
| DOIs | |
| Publication status | Published - Nov 1 2015 |
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Keywords
- Cardiovascular disease
- Cardiovascular events
- Chronic kidney disease
- Hemodialysis initiation
ASJC Scopus subject areas
- Nephrology
Cite this
High cardiovascular event rates occur within the first weeks of starting hemodialysis. / Eckardt, Kai Uwe; Gillespie, Iain A.; Kronenberg, Florian; Richards, Sharon; Stenvinkel, Peter; Anker, Stefan D.; Wheeler, David C.; De Francisco, Angel L.; Marcelli, Daniele; Froissart, Marc; Floege, Jürgen.
In: Kidney International, Vol. 88, No. 5, 01.11.2015, p. 1117-1125.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - High cardiovascular event rates occur within the first weeks of starting hemodialysis
AU - Eckardt, Kai Uwe
AU - Gillespie, Iain A.
AU - Kronenberg, Florian
AU - Richards, Sharon
AU - Stenvinkel, Peter
AU - Anker, Stefan D.
AU - Wheeler, David C.
AU - De Francisco, Angel L.
AU - Marcelli, Daniele
AU - Froissart, Marc
AU - Floege, Jürgen
PY - 2015/11/1
Y1 - 2015/11/1
N2 - Early mortality is high in hemodialysis (HD) patients, but little is known about early cardiovascular event (CVE) rates after HD initiation. To study this we analyzed data in the AROii cohort of incident HD patients from over 300 European Fresenius Medical Care dialysis centers. Weekly rates of a composite of CVEs during the first year and monthly rates of the composite and its constituents (coronary artery, cerebrovascular, peripheral arterial, congestive heart failure, and sudden cardiac death) during the first 2 years after HD initiation were assessed. Of 6308 patients that started dialysis within 7 days, 1449 patients experienced 2405 CVEs over the next 2 years. The first-year CVE rate (30.2/100 person-years; 95% CI, 28.7-31.7) greatly exceeded the second-year rate (19.4/100; 95% CI, 18.1-20.8). Composite CVEs were highest during the first week with increased risk compared with the second year, persisting until the fifth month. Except for sudden cardiac death, temporal patterns of rates for all CVE categories were very similar, with highest rates during the first month and a high-risk period extending to 4 months. Higher or lower cumulative weekly dialysis dose, lower blood flow, and lower net ultrafiltration during dialysis were associated with CVE during the high-risk period, but not during the post high-risk period. Thus, the incidence of CVE in the first weeks after HD initiation is much higher than during subsequent periods which raises concerns that HD initiation may trigger CVEs.
AB - Early mortality is high in hemodialysis (HD) patients, but little is known about early cardiovascular event (CVE) rates after HD initiation. To study this we analyzed data in the AROii cohort of incident HD patients from over 300 European Fresenius Medical Care dialysis centers. Weekly rates of a composite of CVEs during the first year and monthly rates of the composite and its constituents (coronary artery, cerebrovascular, peripheral arterial, congestive heart failure, and sudden cardiac death) during the first 2 years after HD initiation were assessed. Of 6308 patients that started dialysis within 7 days, 1449 patients experienced 2405 CVEs over the next 2 years. The first-year CVE rate (30.2/100 person-years; 95% CI, 28.7-31.7) greatly exceeded the second-year rate (19.4/100; 95% CI, 18.1-20.8). Composite CVEs were highest during the first week with increased risk compared with the second year, persisting until the fifth month. Except for sudden cardiac death, temporal patterns of rates for all CVE categories were very similar, with highest rates during the first month and a high-risk period extending to 4 months. Higher or lower cumulative weekly dialysis dose, lower blood flow, and lower net ultrafiltration during dialysis were associated with CVE during the high-risk period, but not during the post high-risk period. Thus, the incidence of CVE in the first weeks after HD initiation is much higher than during subsequent periods which raises concerns that HD initiation may trigger CVEs.
KW - Cardiovascular disease
KW - Cardiovascular events
KW - Chronic kidney disease
KW - Hemodialysis initiation
UR - http://www.scopus.com/inward/record.url?scp=84947612697&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84947612697&partnerID=8YFLogxK
U2 - 10.1038/ki.2015.117
DO - 10.1038/ki.2015.117
M3 - Article
AN - SCOPUS:84947612697
VL - 88
SP - 1117
EP - 1125
JO - Kidney International
JF - Kidney International
SN - 0085-2538
IS - 5
ER -