High cholesterol affects platelet APP processing in controls and in AD patients

Barbara Borroni, Francesca Colciaghi, Gian Luigi Lenzi, Luigi Caimi, Flaminio Cattabeni, Monica Di Luca, Alessandro Padovani

Research output: Contribution to journalArticle

Abstract

Alzheimer disease (AD) is characterised by a decrease of platelet Amyloid Precursor Protein forms ratio (APPr), which parallels symptoms' severity. Recent studies have suggested that cholesterol might play a role in the pathophysiology of AD by modulating Aβ production. Aim of this study was to evaluate the relationship between serum cholesterol levels and platelet APP processing in controls and AD. Sixty AD patients and 45 age-matched controls (CTRL) were investigated. Neuropsychological assessment, cholesterol dosage and APP forms' evaluation were performed on each subject. CTRL showed lower serum cholesterol levels compared to AD (P

Original languageEnglish
Pages (from-to)631-636
Number of pages6
JournalNeurobiology of Aging
Volume24
Issue number5
DOIs
Publication statusPublished - Sep 2003

Keywords

  • Alzheimer disease
  • Amyloid precursor protein
  • Cholesterol
  • Platelets

ASJC Scopus subject areas

  • Clinical Neurology
  • Biological Psychiatry
  • Developmental Neuroscience
  • Neurology
  • Psychology(all)

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