High circulating levels of endogenous ouabain in the offspring of hypertensive and normotensive individuals

Paolo Manunta, Massimo Iacoviello, Cinzia Forleo, Elisabetta Messaggio, John M. Hamlyn, Katia Lucarelli, Pietro Guida, Roberta Romito, Elisabetta De Tommasi, Giuseppe Bianchi, Paolo Rizzon, Maria Vittoria Pitzalis

Research output: Contribution to journalArticle

26 Citations (Scopus)

Abstract

Objective: Impaired diastolic function and left ventricular hypertrophy can occur early in the natural history of essential hypertension. High circulating levels of endogenous ouabain (EO) have been described in essential hypertension and have also been associated with left ventricular hypertrophy. The aim of this study was to investigate whether these cardiac modifications are related to plasma EO levels in the offspring of hypertensive families. Methods: The study involved 41 subjects with (FAM+) and 45 subjects without (FAM-) a family history of hypertension. Arterial blood pressure, left ventricular geometry and function, and plasma EO levels were measured in each subject Results: Plasma EO levels were higher in the FAM+ subjects (221.5 ± 10.95 versus 179.6 ± 9.58 pmol/l, P = 0.004), and directly correlated with both systolic (r = 0.417, P <0.0001) and diastolic blood pressure (r = 0.333, P = 0.002). Plasma EO was inversely related to an index of cardiac diastolic function determined as the ratio between the early and late peak flow velocity (r = -0.286, P = 0.012) and isovolumetric relaxation time (IVRT) (r = 0.32, P = 0.003). The IVRT was also significantly higher in FAM+, correlated with the IVRT (r = 0.32, P = 0.003). The IVRT was also significantly higher in FAM+, whereas the other echocardiographic parameters were similar to FAM-. Conclusions: Among the offspring of families with a positive history of hypertension, circulating EO levels and blood pressure are increased. Plasma EO levels are related to alterations of some indexes of diastolic heart function in these individuals.

Original languageEnglish
Pages (from-to)1677-1681
Number of pages5
JournalJournal of Hypertension
Volume23
Issue number9
Publication statusPublished - Sep 2005

Fingerprint

Ouabain
Left Ventricular Hypertrophy
Blood Pressure
Hypertension
Natural History
Left Ventricular Function
Arterial Pressure

Keywords

  • High blood pressure
  • Left ventricular hypertrophy
  • Sodium-pump inhibitors

ASJC Scopus subject areas

  • Internal Medicine
  • Endocrinology

Cite this

Manunta, P., Iacoviello, M., Forleo, C., Messaggio, E., Hamlyn, J. M., Lucarelli, K., ... Pitzalis, M. V. (2005). High circulating levels of endogenous ouabain in the offspring of hypertensive and normotensive individuals. Journal of Hypertension, 23(9), 1677-1681.

High circulating levels of endogenous ouabain in the offspring of hypertensive and normotensive individuals. / Manunta, Paolo; Iacoviello, Massimo; Forleo, Cinzia; Messaggio, Elisabetta; Hamlyn, John M.; Lucarelli, Katia; Guida, Pietro; Romito, Roberta; De Tommasi, Elisabetta; Bianchi, Giuseppe; Rizzon, Paolo; Pitzalis, Maria Vittoria.

In: Journal of Hypertension, Vol. 23, No. 9, 09.2005, p. 1677-1681.

Research output: Contribution to journalArticle

Manunta, P, Iacoviello, M, Forleo, C, Messaggio, E, Hamlyn, JM, Lucarelli, K, Guida, P, Romito, R, De Tommasi, E, Bianchi, G, Rizzon, P & Pitzalis, MV 2005, 'High circulating levels of endogenous ouabain in the offspring of hypertensive and normotensive individuals', Journal of Hypertension, vol. 23, no. 9, pp. 1677-1681.
Manunta P, Iacoviello M, Forleo C, Messaggio E, Hamlyn JM, Lucarelli K et al. High circulating levels of endogenous ouabain in the offspring of hypertensive and normotensive individuals. Journal of Hypertension. 2005 Sep;23(9):1677-1681.
Manunta, Paolo ; Iacoviello, Massimo ; Forleo, Cinzia ; Messaggio, Elisabetta ; Hamlyn, John M. ; Lucarelli, Katia ; Guida, Pietro ; Romito, Roberta ; De Tommasi, Elisabetta ; Bianchi, Giuseppe ; Rizzon, Paolo ; Pitzalis, Maria Vittoria. / High circulating levels of endogenous ouabain in the offspring of hypertensive and normotensive individuals. In: Journal of Hypertension. 2005 ; Vol. 23, No. 9. pp. 1677-1681.
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abstract = "Objective: Impaired diastolic function and left ventricular hypertrophy can occur early in the natural history of essential hypertension. High circulating levels of endogenous ouabain (EO) have been described in essential hypertension and have also been associated with left ventricular hypertrophy. The aim of this study was to investigate whether these cardiac modifications are related to plasma EO levels in the offspring of hypertensive families. Methods: The study involved 41 subjects with (FAM+) and 45 subjects without (FAM-) a family history of hypertension. Arterial blood pressure, left ventricular geometry and function, and plasma EO levels were measured in each subject Results: Plasma EO levels were higher in the FAM+ subjects (221.5 ± 10.95 versus 179.6 ± 9.58 pmol/l, P = 0.004), and directly correlated with both systolic (r = 0.417, P <0.0001) and diastolic blood pressure (r = 0.333, P = 0.002). Plasma EO was inversely related to an index of cardiac diastolic function determined as the ratio between the early and late peak flow velocity (r = -0.286, P = 0.012) and isovolumetric relaxation time (IVRT) (r = 0.32, P = 0.003). The IVRT was also significantly higher in FAM+, correlated with the IVRT (r = 0.32, P = 0.003). The IVRT was also significantly higher in FAM+, whereas the other echocardiographic parameters were similar to FAM-. Conclusions: Among the offspring of families with a positive history of hypertension, circulating EO levels and blood pressure are increased. Plasma EO levels are related to alterations of some indexes of diastolic heart function in these individuals.",
keywords = "High blood pressure, Left ventricular hypertrophy, Sodium-pump inhibitors",
author = "Paolo Manunta and Massimo Iacoviello and Cinzia Forleo and Elisabetta Messaggio and Hamlyn, {John M.} and Katia Lucarelli and Pietro Guida and Roberta Romito and {De Tommasi}, Elisabetta and Giuseppe Bianchi and Paolo Rizzon and Pitzalis, {Maria Vittoria}",
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AU - Manunta, Paolo

AU - Iacoviello, Massimo

AU - Forleo, Cinzia

AU - Messaggio, Elisabetta

AU - Hamlyn, John M.

AU - Lucarelli, Katia

AU - Guida, Pietro

AU - Romito, Roberta

AU - De Tommasi, Elisabetta

AU - Bianchi, Giuseppe

AU - Rizzon, Paolo

AU - Pitzalis, Maria Vittoria

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N2 - Objective: Impaired diastolic function and left ventricular hypertrophy can occur early in the natural history of essential hypertension. High circulating levels of endogenous ouabain (EO) have been described in essential hypertension and have also been associated with left ventricular hypertrophy. The aim of this study was to investigate whether these cardiac modifications are related to plasma EO levels in the offspring of hypertensive families. Methods: The study involved 41 subjects with (FAM+) and 45 subjects without (FAM-) a family history of hypertension. Arterial blood pressure, left ventricular geometry and function, and plasma EO levels were measured in each subject Results: Plasma EO levels were higher in the FAM+ subjects (221.5 ± 10.95 versus 179.6 ± 9.58 pmol/l, P = 0.004), and directly correlated with both systolic (r = 0.417, P <0.0001) and diastolic blood pressure (r = 0.333, P = 0.002). Plasma EO was inversely related to an index of cardiac diastolic function determined as the ratio between the early and late peak flow velocity (r = -0.286, P = 0.012) and isovolumetric relaxation time (IVRT) (r = 0.32, P = 0.003). The IVRT was also significantly higher in FAM+, correlated with the IVRT (r = 0.32, P = 0.003). The IVRT was also significantly higher in FAM+, whereas the other echocardiographic parameters were similar to FAM-. Conclusions: Among the offspring of families with a positive history of hypertension, circulating EO levels and blood pressure are increased. Plasma EO levels are related to alterations of some indexes of diastolic heart function in these individuals.

AB - Objective: Impaired diastolic function and left ventricular hypertrophy can occur early in the natural history of essential hypertension. High circulating levels of endogenous ouabain (EO) have been described in essential hypertension and have also been associated with left ventricular hypertrophy. The aim of this study was to investigate whether these cardiac modifications are related to plasma EO levels in the offspring of hypertensive families. Methods: The study involved 41 subjects with (FAM+) and 45 subjects without (FAM-) a family history of hypertension. Arterial blood pressure, left ventricular geometry and function, and plasma EO levels were measured in each subject Results: Plasma EO levels were higher in the FAM+ subjects (221.5 ± 10.95 versus 179.6 ± 9.58 pmol/l, P = 0.004), and directly correlated with both systolic (r = 0.417, P <0.0001) and diastolic blood pressure (r = 0.333, P = 0.002). Plasma EO was inversely related to an index of cardiac diastolic function determined as the ratio between the early and late peak flow velocity (r = -0.286, P = 0.012) and isovolumetric relaxation time (IVRT) (r = 0.32, P = 0.003). The IVRT was also significantly higher in FAM+, correlated with the IVRT (r = 0.32, P = 0.003). The IVRT was also significantly higher in FAM+, whereas the other echocardiographic parameters were similar to FAM-. Conclusions: Among the offspring of families with a positive history of hypertension, circulating EO levels and blood pressure are increased. Plasma EO levels are related to alterations of some indexes of diastolic heart function in these individuals.

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