High cut-off membranes in acute kidney injury and continuous renal replacement therapy

Zaccaria Ricci, Stefano Romagnoli, Claudio Ronco

Research output: Contribution to journalReview articlepeer-review


Innovation in continuous renal replacement therapies (CRRT) utilized to treat acute kidney injury (AKI) and sepsis, has brought new machines and techniques. Part of these new advances are due to the availability of innovative biomaterials and the construction of membranes with larger pores and wide distribution of pore sizes. This includes the creation of a new generation of high cut-off membranes whose utilization in clinical practice is promising for the wide spectrum of solutes that are removed during extracorporeal therapies. However, the enlargement of pore diameters brings some loss of albumin during treatment and this effect is still under evaluation, since there is a possibility that this is detrimental for the patient. A thorough review of the available clinical literature is reported in this paper with a reappraisal of the potential application of these new technologies.

Original languageEnglish
Pages (from-to)657-664
Number of pages8
JournalInternational Journal of Artificial Organs
Issue number12
Publication statusPublished - Dec 1 2017


  • Clearance
  • Continuous renal replacement therapy
  • Cytokine
  • Sepsis

ASJC Scopus subject areas

  • Bioengineering
  • Medicine (miscellaneous)
  • Biomaterials
  • Biomedical Engineering


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