Abstract
High density lipoproteins (HDL) promote the efflux of excess cholesterol from peripheral tissues to the liver for excretion. This ability is responsible for the most relevant antiatherogenic effect of HDL. The ability of HDL to promote cholesterol efflux results also in the modulation of a series of responses in the immune cells involved in atherosclerosis, including monocyte-macrophages, B and T lymphocytes. Furthermore, during inflammation, the composition of this class of lipoproteins varies to a large extent, thus promoting the formation of dysfunctional HDL. The aim of this review is to discuss the emerging role of HDL in modulating the activity of immune cells and immune-inflammatory mediators during atherogenesis.
| Original language | English |
|---|---|
| Pages (from-to) | 401-407 |
| Number of pages | 7 |
| Journal | Journal of Geriatric Cardiology |
| Volume | 9 |
| Issue number | 4 |
| DOIs | |
| Publication status | Published - 2012 |
Fingerprint
Keywords
- Apolipoprotein
- High density lipoproteins
- Immune response
- Sphingosine-1-phosphate
ASJC Scopus subject areas
- Cardiology and Cardiovascular Medicine
- Geriatrics and Gerontology
Cite this
High density lipoproteins and atherosclerosis : Emerging aspects. / Sala, Federica; Catapano, Alberico Luigi; Norata, Giuseppe Danilo.
In: Journal of Geriatric Cardiology, Vol. 9, No. 4, 2012, p. 401-407.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - High density lipoproteins and atherosclerosis
T2 - Emerging aspects
AU - Sala, Federica
AU - Catapano, Alberico Luigi
AU - Norata, Giuseppe Danilo
PY - 2012
Y1 - 2012
N2 - High density lipoproteins (HDL) promote the efflux of excess cholesterol from peripheral tissues to the liver for excretion. This ability is responsible for the most relevant antiatherogenic effect of HDL. The ability of HDL to promote cholesterol efflux results also in the modulation of a series of responses in the immune cells involved in atherosclerosis, including monocyte-macrophages, B and T lymphocytes. Furthermore, during inflammation, the composition of this class of lipoproteins varies to a large extent, thus promoting the formation of dysfunctional HDL. The aim of this review is to discuss the emerging role of HDL in modulating the activity of immune cells and immune-inflammatory mediators during atherogenesis.
AB - High density lipoproteins (HDL) promote the efflux of excess cholesterol from peripheral tissues to the liver for excretion. This ability is responsible for the most relevant antiatherogenic effect of HDL. The ability of HDL to promote cholesterol efflux results also in the modulation of a series of responses in the immune cells involved in atherosclerosis, including monocyte-macrophages, B and T lymphocytes. Furthermore, during inflammation, the composition of this class of lipoproteins varies to a large extent, thus promoting the formation of dysfunctional HDL. The aim of this review is to discuss the emerging role of HDL in modulating the activity of immune cells and immune-inflammatory mediators during atherogenesis.
KW - Apolipoprotein
KW - High density lipoproteins
KW - Immune response
KW - Sphingosine-1-phosphate
UR - http://www.scopus.com/inward/record.url?scp=84874079949&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84874079949&partnerID=8YFLogxK
U2 - 10.3724/SP.J.1263.2011.12282
DO - 10.3724/SP.J.1263.2011.12282
M3 - Article
C2 - 23341845
AN - SCOPUS:84874079949
VL - 9
SP - 401
EP - 407
JO - Journal of Geriatric Cardiology
JF - Journal of Geriatric Cardiology
SN - 1671-5411
IS - 4
ER -