High-dose antioxidant therapy during thrombolysis in patients with acute myocardial infarction

Emanuele Altomare, Paolo Colonna, Carlo D'Agostino, Giustina Castellaneta, Gianluigi Vendemiale, Ignazio Grattagliano, Francesca Cirelli, Francesco Bovenzi, Luigi Colonna

Research output: Contribution to journalArticlepeer-review


This study investigated the effects of 24-hour intravenous infusion of glutathione (GSH) on plasma malondialdehyde (MDA) levels and on clinical recovery after myocardial infarction in 67 patients treated with recombinant tissue-type plasminogen activator (rt-PA) and 29 patients not given rt-PA. Baseline MDA levels were also measured in 20 healthy control subjects matched for sex, age, and smoking habits. Administration of rt-PA resulted in an earlier recovery of ST elevation. A higher number of patients with fast ST recovery, a lower creatine phosphokinase (CPK) maximum peak, earlier CPK peak, and a lower incidence of arrhythmic episodes were among those who received GSH in addition to rt-PA. Patients who did not receive rt-PA showed a rather steady trend of plasma MDA levels. Patients receiving thrombolytic therapy showed increased MDA concentrations beginning 6 hours after starting therapy. However, while the patients treated only with rt-PA showed a continuous increase in MDA levels, those patients who also received GSH had a significant decrease in MDA levels. Plasma MDA levels significantly increased after thrombolysis; administration of GSH appeared to limit some adverse effects associated with reperfusion-induced oxidative stress.

Original languageEnglish
Pages (from-to)131-141
Number of pages11
JournalCurrent Therapeutic Research
Issue number2
Publication statusPublished - 1996

ASJC Scopus subject areas

  • Medicine(all)

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