La chemioterapia intraarteriosa neo-adiuvante superselettiva con carboplatino ad alte dosi nei tumori avanzati cervico-facciali.

Translated title of the contribution: High-dose carboplatin superselective intraarterial chemotherapy in advanced head and neck cancer

M. Benazzo, G. Bernardo, F. Corbella, M. Danova, L. Lanza, F. Zappoli, C. Uggetti, E. Mira

Research output: Contribution to journalArticle

Abstract

Advances in vascular radiology techniques for superselective transfemoral arterial infusion prompted us to evaluate the effects of high-dose rapid regional carboplatin infusion for patients with advanced head and neck squamous cell carcinomas. Twenty untreated patients received three infusions of carboplatin (300-350 mg/m2) every 2 weeks with this method. All the infusions were performed without any complication. Treatment was well tolerated, with moderate (Grade 1-3 WHO) local toxicity (stomatitis, dermatitis and alopecia) and minimal (Grade 1-2 WHO) myelosuppression. The total response index (complete response plus partial response) was 94% for primary tumors and 50% for neck metastases. Neoadjuvant chemotherapy employing superselective rapid infusion of high-dose carboplatin is a feasible, relatively nontoxic, effective technique and may have important applications in multimodality therapy of untreated patients with advanced head and neck cancer.

Original languageItalian
Pages (from-to)30-34
Number of pages5
JournalActa Otorhinolaryngologica Italica
Volume16
Issue number1
Publication statusPublished - Feb 1996

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ASJC Scopus subject areas

  • Otorhinolaryngology

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