High-Dose Chemotherapy and Autologous Hematopoietic Stem Cell Transplantation as Adjuvant Treatment in High-Risk Breast Cancer: Data from the European Group for Blood and Marrow Transplantation Registry

M. Martino, F. Lanza, L. Pavesi, M. Öztürk, D. Blaise, R. Leno Núñez, H. C. Schouten, A. Bosi, U. De Giorgi, D. Generali, G. Rosti, A. Necchi, A. Ravelli, C. Bengala, Manuela Badoglio, P. Pedrazzoli, Marco Bregni

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Abstract

The aim of this retrospective study was to assess toxicity and efficacy of adjuvant high-dose chemotherapy (HDC) and autologous hematopoietic stem cell transplantation (AHSCT) in 583 high-risk breast cancer (BC) patients (>3 positive nodes) who were transplanted between 1995 and 2005 in Europe. All patients received surgery before transplant, and 55 patients (9.5%) received neoadjuvant treatment before surgery. Median age was 47.1 years, 57.3% of patients were premenopausal at treatment, 56.5% had endocrine-responsive tumors, 19.5% had a human epidermal growth factor receptor 2 (HER2)-negative tumor, and 72.4% had ≥10 positive lymph nodes at surgery. Seventy-nine percent received a single HDC procedure. Overall transplant-related mortality was 1.9%, at.9% between 2001 and 2005, whereas secondary tumor-related mortality was.9%. With a median follow-up of 120 months, overall survival and disease-free survival rates at 5 and 10 years in the whole population were 75% and 64% and 58% and 44%, respectively. Subgroup analysis demonstrated that rates of overall survival were significantly better in patients with endocrine-responsive tumors,
Original languageEnglish
Pages (from-to)475-481
Number of pages7
JournalBiology of Blood and Marrow Transplantation
Volume22
Issue number3
DOIs
Publication statusPublished - 2016

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Keywords

  • Autologous hematopoietic stem cell transplantation
  • High-dose chemotherapy
  • High-risk breast cancer

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