@article{93f3a385c31d4eb892a5a73286fc31d7,
title = "High-Dose Chemotherapy and Autologous Hematopoietic Stem Cell Transplantation as Adjuvant Treatment in High-Risk Breast Cancer: Data from the European Group for Blood and Marrow Transplantation Registry",
abstract = "The aim of this retrospective study was to assess toxicity and efficacy of adjuvant high-dose chemotherapy (HDC) and autologous hematopoietic stem cell transplantation (AHSCT) in 583 high-risk breast cancer (BC) patients (>3 positive nodes) who were transplanted between 1995 and 2005 in Europe. All patients received surgery before transplant, and 55 patients (9.5%) received neoadjuvant treatment before surgery. Median age was 47.1 years, 57.3% of patients were premenopausal at treatment, 56.5% had endocrine-responsive tumors, 19.5% had a human epidermal growth factor receptor 2 (HER2)-negative tumor, and 72.4% had ≥10 positive lymph nodes at surgery. Seventy-nine percent received a single HDC procedure. Overall transplant-related mortality was 1.9%, at.9% between 2001 and 2005, whereas secondary tumor-related mortality was.9%. With a median follow-up of 120 months, overall survival and disease-free survival rates at 5 and 10 years in the whole population were 75% and 64% and 58% and 44%, respectively. Subgroup analysis demonstrated that rates of overall survival were significantly better in patients with endocrine-responsive tumors, ",
keywords = "Autologous hematopoietic stem cell transplantation, High-dose chemotherapy, High-risk breast cancer",
author = "M. Martino and F. Lanza and L. Pavesi and M. {\"O}zt{\"u}rk and D. Blaise and {Leno N{\'u}{\~n}ez}, R. and Schouten, {H. C.} and A. Bosi and {De Giorgi}, U. and D. Generali and G. Rosti and A. Necchi and A. Ravelli and C. Bengala and Manuela Badoglio and P. Pedrazzoli and Marco Bregni",
note = "Export Date: 14 March 2017 CODEN: BBMTF Correspondence Address: Martino, M.; Hematology and Stem Cell Transplant Unit, Azienda Ospedaliera BMMItaly; email: maxmartino@live.com References: Pedrazzoli, P., Martino, M., Delfanti, S., High-dose chemotherapy with autologous hematopoietic stem cell transplantation for high-risk primary breast cancer (2015) J Natl Cancer Inst Monogr, 51, pp. 70-75; Hortobagyi, G.N., What is the role of high-dose chemotherapy in the era of targeted therapies? (2004) J Clin Oncol, 22, pp. 2263-2266; Castagna, L., Martino, M., Are there still reasons to believe that high-dose chemotherapy has a role in breast cancer management? 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year = "2016",
doi = "10.1016/j.bbmt.2015.12.011",
language = "English",
volume = "22",
pages = "475--481",
journal = "Biology of Blood and Marrow Transplantation",
issn = "1083-8791",
publisher = "Elsevier Inc.",
number = "3",
}