High-Dose Chemotherapy for Adult-Type Ovarian Granulosa Cell Tumors: A Retrospective Study of the European Society for Blood and Marrow Transplantation

Ugo De Giorgi, Emmanuelle Nicolas-Virelizier, Manuela Badoglio, Peter Bader, Sandrine Richard, Johan Maertens, Francesco Lanza, Marco Bregni

Research output: Contribution to journalArticlepeer-review

Abstract

Objectives A few small retrospective series reported results with salvage chemotherapy for malignant ovarian adult-type granulosa cell tumors (GCTs), whereas no data are available on high-dose chemotherapy (HDC) with hematopoietic progenitor cell support (HSCS) in these patients. The aim of this study was to analyze the available data of HDC for adult-type GCTs. Methods We conducted a retrospective analysis of ovarian cancer treated with salvage HDC registered with the European Society for Blood and Marrow Transplantation. Results Of 203 adult female patients with a diagnosis of nonepithelial ovarian cancer treated with salvage HDC with HSCS and registered with the European Society for Blood and Marrow Transplantation, 4 (2%) patients were affected by GCTs. All 4 patients had ovarian adult-type GCTs that relapsed/progressed after first-line chemotherapy. The conditioning regimens included a platinum agent in all 4 patients. Bone marrow recovery was promptly achieved; neither treatment-related deaths or life-threatening toxicities occurred. At a median follow-up of 8.5 months, all patients reported a progressive disease. The patient who underwent multicycle HDC enjoyed a long-term remission of 84 months before progression and is the only one alive after 94+ months. Conclusions We showed for the first time a case with long-lasting response to salvage multicycle HDC and HSCS in adult-type GCTs.

Original languageEnglish
Pages (from-to)248-251
Number of pages4
JournalInternational Journal of Gynecological Cancer
Volume27
Issue number2
DOIs
Publication statusPublished - Feb 1 2017

Keywords

  • Adult-type ovarian granulosa cell tumors
  • High-dose chemotherapy
  • Ovarian cancer
  • Salvage chemotherapy

ASJC Scopus subject areas

  • Oncology
  • Obstetrics and Gynaecology

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