Abstract
A substantial percentage of patients with advanced ovarian cancer will progress or relapse after platinum-based front therapies and will require salvage chemotherapy. In order to evaluate feasibility and effectiveness of high dose platinum (HD-CDDP) nine patients with ovarian cancer were treated with HD-CDDP while progressing after conventional doses of the same drug. Cisplatin 40 mg/M2 d. 1 → 5 q. 28 days, was administered with forced chloruresis for a total of fifteen cycles. Preliminary results show a promising 44.4% response rate with acceptable toxicity: only one patient had to discontinue treatment because of severe combined toxicity including infection, mucositis, shaking tremors, ototoxicity and palmar hyperkeratosis.
Original language | English |
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Pages (from-to) | 139-142 |
Number of pages | 4 |
Journal | Chemioterapia |
Volume | 4 |
Issue number | 2 |
Publication status | Published - 1985 |
ASJC Scopus subject areas
- Pharmacology (medical)
- Microbiology (medical)