High-dose cisplatin and bleomycin neoadjuvant chemotherapy plus radical surgery in locally advanced cervical carcinoma: A preliminary report

Pierluigi Benedetti Panici, Stefano Greggi, Giovanni Scambia, Guglielmo Ragusa, Gabriela Baiocchi, Francesco Battaglia, Ferdinando Coronetta, Salvatore Mancuso

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Abstract

One course of chemotherapy containing cisplatin and bleomycin as a neoadjuvant treatment was given to 26 consecutive patients with previously untreated stage IB (bulky disease)-III cervical carcinoma and followed by radical surgery. After chemotherapy responses were detected in 23 patients (5 complete and 18 partial; overall, 88%) and permitted radical surgery in 21 cases (81%). Surgery consisted of type III-IV radical hysterectomy plus systematic para-aortic and pelvic lymphadenectomy. At histologic examination, complete responses were found in 5 (19%) and partial responses in 16 (62%) cases. The average number of lymph nodes removed was 61 (range, 38-118). A lower than expected incidence of lymph node metastases was detected ( 2 21, 9.5%). The chemotherapy-induced toxicity was mainly represented by nausea and vomiting. Chemotherapy did not seem to complicate surgery in these circumstances, even though moderate-degree postoperative complications occurred in 48% of cases. Eighteen months median follow-up time (range, 11-23) from hystological diagnosis has been reached in the operated patients, and no recurrences have been detected so far.

Original languageEnglish
Pages (from-to)212-216
Number of pages5
JournalGynecologic Oncology
Volume41
Issue number3
DOIs
Publication statusPublished - 1991

ASJC Scopus subject areas

  • Obstetrics and Gynaecology
  • Oncology

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