High-dose cisplatin and bleomycin neoadjuvant chemotherapy plus radical surgery in locally advanced cervical carcinoma: A preliminary report

Pierluigi Benedetti Panici, Stefano Greggi, Giovanni Scambia, Guglielmo Ragusa, Gabriela Baiocchi, Francesco Battaglia, Ferdinando Coronetta, Salvatore Mancuso

Research output: Contribution to journalArticle

68 Citations (Scopus)

Abstract

One course of chemotherapy containing cisplatin and bleomycin as a neoadjuvant treatment was given to 26 consecutive patients with previously untreated stage IB (bulky disease)-III cervical carcinoma and followed by radical surgery. After chemotherapy responses were detected in 23 patients (5 complete and 18 partial; overall, 88%) and permitted radical surgery in 21 cases (81%). Surgery consisted of type III-IV radical hysterectomy plus systematic para-aortic and pelvic lymphadenectomy. At histologic examination, complete responses were found in 5 (19%) and partial responses in 16 (62%) cases. The average number of lymph nodes removed was 61 (range, 38-118). A lower than expected incidence of lymph node metastases was detected ( 2 21, 9.5%). The chemotherapy-induced toxicity was mainly represented by nausea and vomiting. Chemotherapy did not seem to complicate surgery in these circumstances, even though moderate-degree postoperative complications occurred in 48% of cases. Eighteen months median follow-up time (range, 11-23) from hystological diagnosis has been reached in the operated patients, and no recurrences have been detected so far.

Original languageEnglish
Pages (from-to)212-216
Number of pages5
JournalGynecologic Oncology
Volume41
Issue number3
DOIs
Publication statusPublished - 1991

Fingerprint

Bleomycin
Cisplatin
Carcinoma
Drug Therapy
Lymph Nodes
Neoadjuvant Therapy
Lymph Node Excision
Hysterectomy
Nausea
Vomiting
Neoplasm Metastasis
Recurrence
Incidence

ASJC Scopus subject areas

  • Obstetrics and Gynaecology
  • Oncology

Cite this

High-dose cisplatin and bleomycin neoadjuvant chemotherapy plus radical surgery in locally advanced cervical carcinoma : A preliminary report. / Panici, Pierluigi Benedetti; Greggi, Stefano; Scambia, Giovanni; Ragusa, Guglielmo; Baiocchi, Gabriela; Battaglia, Francesco; Coronetta, Ferdinando; Mancuso, Salvatore.

In: Gynecologic Oncology, Vol. 41, No. 3, 1991, p. 212-216.

Research output: Contribution to journalArticle

Panici, Pierluigi Benedetti ; Greggi, Stefano ; Scambia, Giovanni ; Ragusa, Guglielmo ; Baiocchi, Gabriela ; Battaglia, Francesco ; Coronetta, Ferdinando ; Mancuso, Salvatore. / High-dose cisplatin and bleomycin neoadjuvant chemotherapy plus radical surgery in locally advanced cervical carcinoma : A preliminary report. In: Gynecologic Oncology. 1991 ; Vol. 41, No. 3. pp. 212-216.
@article{b078fa14feef41f3b2e7cbea7104eec2,
title = "High-dose cisplatin and bleomycin neoadjuvant chemotherapy plus radical surgery in locally advanced cervical carcinoma: A preliminary report",
abstract = "One course of chemotherapy containing cisplatin and bleomycin as a neoadjuvant treatment was given to 26 consecutive patients with previously untreated stage IB (bulky disease)-III cervical carcinoma and followed by radical surgery. After chemotherapy responses were detected in 23 patients (5 complete and 18 partial; overall, 88{\%}) and permitted radical surgery in 21 cases (81{\%}). Surgery consisted of type III-IV radical hysterectomy plus systematic para-aortic and pelvic lymphadenectomy. At histologic examination, complete responses were found in 5 (19{\%}) and partial responses in 16 (62{\%}) cases. The average number of lymph nodes removed was 61 (range, 38-118). A lower than expected incidence of lymph node metastases was detected ( 2 21, 9.5{\%}). The chemotherapy-induced toxicity was mainly represented by nausea and vomiting. Chemotherapy did not seem to complicate surgery in these circumstances, even though moderate-degree postoperative complications occurred in 48{\%} of cases. Eighteen months median follow-up time (range, 11-23) from hystological diagnosis has been reached in the operated patients, and no recurrences have been detected so far.",
author = "Panici, {Pierluigi Benedetti} and Stefano Greggi and Giovanni Scambia and Guglielmo Ragusa and Gabriela Baiocchi and Francesco Battaglia and Ferdinando Coronetta and Salvatore Mancuso",
year = "1991",
doi = "10.1016/0090-8258(91)90310-2",
language = "English",
volume = "41",
pages = "212--216",
journal = "Gynecologic Oncology",
issn = "0090-8258",
publisher = "Academic Press Inc.",
number = "3",

}

TY - JOUR

T1 - High-dose cisplatin and bleomycin neoadjuvant chemotherapy plus radical surgery in locally advanced cervical carcinoma

T2 - A preliminary report

AU - Panici, Pierluigi Benedetti

AU - Greggi, Stefano

AU - Scambia, Giovanni

AU - Ragusa, Guglielmo

AU - Baiocchi, Gabriela

AU - Battaglia, Francesco

AU - Coronetta, Ferdinando

AU - Mancuso, Salvatore

PY - 1991

Y1 - 1991

N2 - One course of chemotherapy containing cisplatin and bleomycin as a neoadjuvant treatment was given to 26 consecutive patients with previously untreated stage IB (bulky disease)-III cervical carcinoma and followed by radical surgery. After chemotherapy responses were detected in 23 patients (5 complete and 18 partial; overall, 88%) and permitted radical surgery in 21 cases (81%). Surgery consisted of type III-IV radical hysterectomy plus systematic para-aortic and pelvic lymphadenectomy. At histologic examination, complete responses were found in 5 (19%) and partial responses in 16 (62%) cases. The average number of lymph nodes removed was 61 (range, 38-118). A lower than expected incidence of lymph node metastases was detected ( 2 21, 9.5%). The chemotherapy-induced toxicity was mainly represented by nausea and vomiting. Chemotherapy did not seem to complicate surgery in these circumstances, even though moderate-degree postoperative complications occurred in 48% of cases. Eighteen months median follow-up time (range, 11-23) from hystological diagnosis has been reached in the operated patients, and no recurrences have been detected so far.

AB - One course of chemotherapy containing cisplatin and bleomycin as a neoadjuvant treatment was given to 26 consecutive patients with previously untreated stage IB (bulky disease)-III cervical carcinoma and followed by radical surgery. After chemotherapy responses were detected in 23 patients (5 complete and 18 partial; overall, 88%) and permitted radical surgery in 21 cases (81%). Surgery consisted of type III-IV radical hysterectomy plus systematic para-aortic and pelvic lymphadenectomy. At histologic examination, complete responses were found in 5 (19%) and partial responses in 16 (62%) cases. The average number of lymph nodes removed was 61 (range, 38-118). A lower than expected incidence of lymph node metastases was detected ( 2 21, 9.5%). The chemotherapy-induced toxicity was mainly represented by nausea and vomiting. Chemotherapy did not seem to complicate surgery in these circumstances, even though moderate-degree postoperative complications occurred in 48% of cases. Eighteen months median follow-up time (range, 11-23) from hystological diagnosis has been reached in the operated patients, and no recurrences have been detected so far.

UR - http://www.scopus.com/inward/record.url?scp=0025738987&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0025738987&partnerID=8YFLogxK

U2 - 10.1016/0090-8258(91)90310-2

DO - 10.1016/0090-8258(91)90310-2

M3 - Article

C2 - 1714417

AN - SCOPUS:0025738987

VL - 41

SP - 212

EP - 216

JO - Gynecologic Oncology

JF - Gynecologic Oncology

SN - 0090-8258

IS - 3

ER -