High-dose famotidine in the maintenance treatment of refractory esophagitis

Results of a ''medium-term'' open study

G. Bianchi-Porro, F. Pace, O. Sangaletti, A. Peracchia, L. Bonavina, S. Vigneri, R. Termini

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

Forty-four patients with esophagitis refractory to standard H2-blocker therapy, who had healed after a 4- to 16-wk course with either 20-40 mg omeprazole or ranitidine at doses of 300-600 mg daily in a randomized double-blind study, commenced a 3-month maintenance course of therapy with 40 mg bid famotidine. The aims of this investigation were to assess the effectiveness of this regimen in preventing recurrence of esophagitis lesions and symptoms in this subgroup of patients with therapy-resistant disease and to verify whether patients previously healed with omeprazole have a higher recurrence rate than those healed with ranitidine. The results of the study show that, despite the high dose of famotidine, 48% of patients relapsed within 3 months, a third of whom were asymptomatic. Moreover, previous omeprazole treatment is associated with a significantly higher risk of recurrence.

Original languageEnglish
Pages (from-to)1585-1587
Number of pages3
JournalAmerican Journal of Gastroenterology
Volume86
Issue number11
Publication statusPublished - 1991

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Famotidine
Esophagitis
Omeprazole
Ranitidine
Recurrence
Therapeutics
Double-Blind Method
Maintenance

ASJC Scopus subject areas

  • Gastroenterology

Cite this

Bianchi-Porro, G., Pace, F., Sangaletti, O., Peracchia, A., Bonavina, L., Vigneri, S., & Termini, R. (1991). High-dose famotidine in the maintenance treatment of refractory esophagitis: Results of a ''medium-term'' open study. American Journal of Gastroenterology, 86(11), 1585-1587.

High-dose famotidine in the maintenance treatment of refractory esophagitis : Results of a ''medium-term'' open study. / Bianchi-Porro, G.; Pace, F.; Sangaletti, O.; Peracchia, A.; Bonavina, L.; Vigneri, S.; Termini, R.

In: American Journal of Gastroenterology, Vol. 86, No. 11, 1991, p. 1585-1587.

Research output: Contribution to journalArticle

Bianchi-Porro, G, Pace, F, Sangaletti, O, Peracchia, A, Bonavina, L, Vigneri, S & Termini, R 1991, 'High-dose famotidine in the maintenance treatment of refractory esophagitis: Results of a ''medium-term'' open study', American Journal of Gastroenterology, vol. 86, no. 11, pp. 1585-1587.
Bianchi-Porro, G. ; Pace, F. ; Sangaletti, O. ; Peracchia, A. ; Bonavina, L. ; Vigneri, S. ; Termini, R. / High-dose famotidine in the maintenance treatment of refractory esophagitis : Results of a ''medium-term'' open study. In: American Journal of Gastroenterology. 1991 ; Vol. 86, No. 11. pp. 1585-1587.
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