High-dose folinic acid (FA) and fluorouracil (FU) plus or minus thymostimulin (TS) for treatment of metastatic colorectal cancer: Results of a randomized multicenter clinical trial

G. Mustacchi, L. Pavesi, S. Milani, V. Iaffaioli, A. Caraco, G. Comella, A. Contu, A. Farris, G. Artado-Parinello, M. Narcisi, F. Brema, A. Beni, C. Bumma

Research output: Contribution to journalArticle

Abstract

The purpose of this study was to ascertain the possible protective effect of thymostimulin (TS) on chemotherapy-induced leukopenia and related febrile episodes, beside the potential of improving therapeutic efficacy and tolerability of high-dose folinic acid (FA) plus fluorouracil (FU) in metastatic colorectal cancer. In 211 evaluable patients the objective responses were 19/105 (18%) in the FA-FU arm versus 32/106 (30%) obtained with the same regimen plus TS. The difference was statistically significant (p = 0.02). No difference was observed in terms of hematological toxicity, while the TS treated patients experienced a significantly lower incidence of mucositits and diarrhoea (p = 0.03). No significant differences were recorded in the incidence of febrile episodes and other treatment-related toxicities. The possibility of improving response to chemotherapy in advanced colorectal cancer without increasing systemic toxicity is particularly interesting and deserves further attention.

Original languageEnglish
Pages (from-to)617-619
Number of pages3
JournalAnticancer Research
Volume14
Issue number2 B
Publication statusPublished - 1994

Keywords

  • Colorectal cancer
  • Folinic acid
  • Modulation
  • Thymostimulin

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

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    Mustacchi, G., Pavesi, L., Milani, S., Iaffaioli, V., Caraco, A., Comella, G., Contu, A., Farris, A., Artado-Parinello, G., Narcisi, M., Brema, F., Beni, A., & Bumma, C. (1994). High-dose folinic acid (FA) and fluorouracil (FU) plus or minus thymostimulin (TS) for treatment of metastatic colorectal cancer: Results of a randomized multicenter clinical trial. Anticancer Research, 14(2 B), 617-619.