Two patients were treated with treatment-resistant polymyositis with intravenous immunoglobulin over four days at a dose of 0.4 g/kg/day. Clinical recovery followed within two months. Serum creatine kinase (CK) activity decreased to normal, and a clear improvement in muscle strength was observed. One patient showed neither clinical relapses nor increase in serum CK activity after 20 months. The other showed a mild increase in serum CK activity after 24 months and was successfully retreated with intravenous immunoglobulin. There were no significant adverse side effects.
|Number of pages||3|
|Journal||Journal of Neurology, Neurosurgery and Psychiatry|
|Publication status||Published - 1992|
ASJC Scopus subject areas
- Psychiatry and Mental health
- Neuropsychology and Physiological Psychology