High-dose methylprednisolone treatment-induced changes in immunological parameters in progressive ms patients

A. Dufour, A. Salmaggi, L. La Mantia, M. Eoli, A. Nespolo, C. Milanese

Research output: Contribution to journalArticle

Abstract

The effect of High-Dose Methylprednisolone (HD-MP) treatment on Peripheral Blood (PB) and Cerebrospinal Fluid (CSF) immune parameters was investigated in 9 patients with relapsing-progressive Multiple Sclerosis (MS). Short-time effects included reduction of the percentage of CD3+, CD4+ and CD4+CD45RA+ PB lymphocytes and increase in CD3-CD56+ cells. At the end of the treatment, only increase in PB CD19+ and in CSF CD8+ CD8+CD28+ and decrease of CSF CD4+CD45RA- and serum IL2R levels were observed. No changes in CD11a+CD4+, CD18+CD4+ and CD18+CD14+ PB cells were observed after treatment. The results further stress the complex and multifaceted action of HD-MP on immune parameters.

Original languageEnglish
Pages (from-to)119-128
Number of pages10
JournalInternational Journal of Neuroscience
Volume75
Issue number1-2
DOIs
Publication statusPublished - 1994

Fingerprint

Methylprednisolone
Cerebrospinal Fluid
Chronic Progressive Multiple Sclerosis
Blood Cells
Therapeutics
Lymphocytes
Serum

Keywords

  • HD-MP
  • IL2R levels
  • MNCs subsets
  • MS

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

High-dose methylprednisolone treatment-induced changes in immunological parameters in progressive ms patients. / Dufour, A.; Salmaggi, A.; Mantia, L. La; Eoli, M.; Nespolo, A.; Milanese, C.

In: International Journal of Neuroscience, Vol. 75, No. 1-2, 1994, p. 119-128.

Research output: Contribution to journalArticle

Dufour, A. ; Salmaggi, A. ; Mantia, L. La ; Eoli, M. ; Nespolo, A. ; Milanese, C. / High-dose methylprednisolone treatment-induced changes in immunological parameters in progressive ms patients. In: International Journal of Neuroscience. 1994 ; Vol. 75, No. 1-2. pp. 119-128.
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