High-dose methylprednisolone treatment-induced changes in immunological parameters in progressive ms patients

A. Dufour, A. Salmaggi, L. La Mantia, M. Eoli, A. Nespolo, C. Milanese

Research output: Contribution to journalArticlepeer-review

Abstract

The effect of High-Dose Methylprednisolone (HD-MP) treatment on Peripheral Blood (PB) and Cerebrospinal Fluid (CSF) immune parameters was investigated in 9 patients with relapsing-progressive Multiple Sclerosis (MS). Short-time effects included reduction of the percentage of CD3+, CD4+ and CD4+CD45RA+ PB lymphocytes and increase in CD3-CD56+ cells. At the end of the treatment, only increase in PB CD19+ and in CSF CD8+ CD8+CD28+ and decrease of CSF CD4+CD45RA- and serum IL2R levels were observed. No changes in CD11a+CD4+, CD18+CD4+ and CD18+CD14+ PB cells were observed after treatment. The results further stress the complex and multifaceted action of HD-MP on immune parameters.

Original languageEnglish
Pages (from-to)119-128
Number of pages10
JournalInternational Journal of Neuroscience
Volume75
Issue number1-2
DOIs
Publication statusPublished - 1994

Keywords

  • HD-MP
  • IL2R levels
  • MNCs subsets
  • MS

ASJC Scopus subject areas

  • Neuroscience(all)

Fingerprint Dive into the research topics of 'High-dose methylprednisolone treatment-induced changes in immunological parameters in progressive ms patients'. Together they form a unique fingerprint.

Cite this