High-dose radiation-induced meningiomas following acute lymphoblastic leukemia in children

Maurizio Salvati, Luigi Cervoni, Marco Artico

Research output: Contribution to journalArticle

23 Citations (Scopus)

Abstract

The authors review three personal cases of patients who developed cerebral meningiomas following high-dose radiotherapy for acute lymphoblastic leukemia. Two patients were female and one male. Their ages when the leukemia appeared were between 11 and 15 years. All patients were treated with a course of prophylactic irradiation to the neuraxis for a total dose of 24 Gy. After an average interval of 10.4 years, all three patients presented a meningioma; histologically, one was meningothelial and two were fibrous. All three meningiomas presented atypical features. At follow-up 1, 4, and 4 years respectively after surgery, none of these patients presents neurological deficits or neuroradiological signs of recurrence. Forty-nine cases of high-dose radiation-induced meningioma are also reviewed.

Original languageEnglish
Pages (from-to)266-269
Number of pages4
JournalChild's Nervous System
Volume12
Issue number5
Publication statusPublished - May 1996

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Precursor Cell Lymphoblastic Leukemia-Lymphoma
Meningioma
Leukemia
Radiotherapy
Radiation induced meningioma
Recurrence

Keywords

  • Meningioma
  • Radiotherapy

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Clinical Neurology

Cite this

High-dose radiation-induced meningiomas following acute lymphoblastic leukemia in children. / Salvati, Maurizio; Cervoni, Luigi; Artico, Marco.

In: Child's Nervous System, Vol. 12, No. 5, 05.1996, p. 266-269.

Research output: Contribution to journalArticle

Salvati, M, Cervoni, L & Artico, M 1996, 'High-dose radiation-induced meningiomas following acute lymphoblastic leukemia in children', Child's Nervous System, vol. 12, no. 5, pp. 266-269.
Salvati, Maurizio ; Cervoni, Luigi ; Artico, Marco. / High-dose radiation-induced meningiomas following acute lymphoblastic leukemia in children. In: Child's Nervous System. 1996 ; Vol. 12, No. 5. pp. 266-269.
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