High-dose versus low-dose cisplatin in advanced head and neck squamous carcinoma

A randomized study

A. Veronesi, V. Zagonel, U. Tirelli, E. Galligioni, S. Tumolo, L. Barzan, M. Lorenzini, R. Comoretto, E. Grigoletto

Research output: Contribution to journalArticle

43 Citations (Scopus)

Abstract

From November 1981 to February 1983, 64 patients with advanced head and neck squamous carcinoma were randomly treated with either high-dise (120 mg/m2) or low-dose (60 mg/m2) cisplatin. Of the 62 eligible patients, 59 were evaluable: the response rate observed in patients receiving high-dose and low-dose cisplatin was 16.1% and 17.8%, respectively. Survival was superimposable in the two treatment arms. No evidence of dose dependency of cisplatin activity in advanced head and neck squamous carcinoma was noted in this randomized trial.

Original languageEnglish
Pages (from-to)1105-1108
Number of pages4
JournalJournal of Clinical Oncology
Volume3
Issue number8
Publication statusPublished - 1985

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Cisplatin
Squamous Cell Carcinoma
Neck
Head
Arm
Survival
Therapeutics

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Veronesi, A., Zagonel, V., Tirelli, U., Galligioni, E., Tumolo, S., Barzan, L., ... Grigoletto, E. (1985). High-dose versus low-dose cisplatin in advanced head and neck squamous carcinoma: A randomized study. Journal of Clinical Oncology, 3(8), 1105-1108.

High-dose versus low-dose cisplatin in advanced head and neck squamous carcinoma : A randomized study. / Veronesi, A.; Zagonel, V.; Tirelli, U.; Galligioni, E.; Tumolo, S.; Barzan, L.; Lorenzini, M.; Comoretto, R.; Grigoletto, E.

In: Journal of Clinical Oncology, Vol. 3, No. 8, 1985, p. 1105-1108.

Research output: Contribution to journalArticle

Veronesi, A, Zagonel, V, Tirelli, U, Galligioni, E, Tumolo, S, Barzan, L, Lorenzini, M, Comoretto, R & Grigoletto, E 1985, 'High-dose versus low-dose cisplatin in advanced head and neck squamous carcinoma: A randomized study', Journal of Clinical Oncology, vol. 3, no. 8, pp. 1105-1108.
Veronesi, A. ; Zagonel, V. ; Tirelli, U. ; Galligioni, E. ; Tumolo, S. ; Barzan, L. ; Lorenzini, M. ; Comoretto, R. ; Grigoletto, E. / High-dose versus low-dose cisplatin in advanced head and neck squamous carcinoma : A randomized study. In: Journal of Clinical Oncology. 1985 ; Vol. 3, No. 8. pp. 1105-1108.
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