Objective: To compare efficacy and tolerance of two high doses of Senna (150 and 300 mg) and to construct a model able to predict poor colon cleansing. Methods: 473 in-patients referred for colonoscopy were prospectively enrolled and randomly allocated to two groups treated with 150 or 300 mg of senna alkaloids. Results: Colonoscopy was impossible (repetition was necessary) in six patients treated with 300 mg (2.7%) and in 38 patients (15.2%) treated with 150 mg (P=0.000006). No significant differences in side effects were observed between the two groups. The model of poor cleansing prediction proved only the positive significance of the dose of Senna (P=0.0006) and of the female sex (P=0.03). Conclusions: 300 mg of Senna resulted more efficacious than 150 and both doses were well tolerated; the positive predictive significance of the Senna dose and of the female sex was also shown by the logistic regression analysis.
|Number of pages||4|
|Journal||Giornale Italiano di Endoscopia Digestiva|
|Publication status||Published - 1996|
- colon cleansing
- colonoscopy preparation
ASJC Scopus subject areas