High doses of Senna for colon cleansing

G. Frigerio, G. Imperiali, N. Lenoci, A. Sangiovanni, G. C. Spinzi, E. Strocchi, V. Terruzzi, G. Minoli

Research output: Contribution to journalArticle


Objective: To compare efficacy and tolerance of two high doses of Senna (150 and 300 mg) and to construct a model able to predict poor colon cleansing. Methods: 473 in-patients referred for colonoscopy were prospectively enrolled and randomly allocated to two groups treated with 150 or 300 mg of senna alkaloids. Results: Colonoscopy was impossible (repetition was necessary) in six patients treated with 300 mg (2.7%) and in 38 patients (15.2%) treated with 150 mg (P=0.000006). No significant differences in side effects were observed between the two groups. The model of poor cleansing prediction proved only the positive significance of the dose of Senna (P=0.0006) and of the female sex (P=0.03). Conclusions: 300 mg of Senna resulted more efficacious than 150 and both doses were well tolerated; the positive predictive significance of the Senna dose and of the female sex was also shown by the logistic regression analysis.

Original languageEnglish
Pages (from-to)181-184
Number of pages4
JournalGiornale Italiano di Endoscopia Digestiva
Issue number3
Publication statusPublished - 1996


  • colon cleansing
  • colonoscopy preparation
  • endoscopy
  • Senna

ASJC Scopus subject areas

  • Gastroenterology

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    Frigerio, G., Imperiali, G., Lenoci, N., Sangiovanni, A., Spinzi, G. C., Strocchi, E., Terruzzi, V., & Minoli, G. (1996). High doses of Senna for colon cleansing. Giornale Italiano di Endoscopia Digestiva, 19(3), 181-184.