TY - JOUR
T1 - High efficiency preparation of L-[S-methyl-11C]methionine by on-column [11C]methylation on C18 Sep-Pak
AU - Pascali, Claudio
AU - Bogni, Anna
AU - Iwata, Ren
AU - Decise, Donatella
AU - Crippa, Flavio
AU - Bombardieri, Emilio
PY - 1999
Y1 - 1999
N2 - A novel approach to the synthesis of L-[S-methyl-11C]methionine, (11C]MET) is described which involves a commercial C18 Sep-Pak Plus as a solid-phase support material for the [11C]methylation step. The present method, which uses [11C]CH3I produced by the classical LiAlH4/HI route, supplies [11C]MET ready for injection within 11 min from the end of bombardment (EOB) with a radiochemical yield, decay corrected at EOB, of 78% and a radiochemical purity at the end of synthesis (EOS) higher than 99%. The required setup is extremely simple and easy to automate and can be reset for a further synthesis within few minutes. Moreover, due to its versatility, the method can be utilized for the production of other radiopharmaceuticals requiring a simple [11C]methylation.
AB - A novel approach to the synthesis of L-[S-methyl-11C]methionine, (11C]MET) is described which involves a commercial C18 Sep-Pak Plus as a solid-phase support material for the [11C]methylation step. The present method, which uses [11C]CH3I produced by the classical LiAlH4/HI route, supplies [11C]MET ready for injection within 11 min from the end of bombardment (EOB) with a radiochemical yield, decay corrected at EOB, of 78% and a radiochemical purity at the end of synthesis (EOS) higher than 99%. The required setup is extremely simple and easy to automate and can be reset for a further synthesis within few minutes. Moreover, due to its versatility, the method can be utilized for the production of other radiopharmaceuticals requiring a simple [11C]methylation.
KW - [C]methionine
KW - On-column reaction
KW - PET
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U2 - 10.1002/(SICI)1099-1344(199908)42:8<715::AID-JLCR224>3.0.CO;2-3
DO - 10.1002/(SICI)1099-1344(199908)42:8<715::AID-JLCR224>3.0.CO;2-3
M3 - Article
AN - SCOPUS:0032837043
VL - 42
SP - 715
EP - 724
JO - Journal of Labelled Compounds and Radiopharmaceuticals
JF - Journal of Labelled Compounds and Radiopharmaceuticals
SN - 0362-4803
IS - 8
ER -