High eradication rates of Helicobacter pylori with a new sequential treatment

A. Zullo, D. Vaira, N. Vakil, C. Hassan, L. Gatta, C. Ricci, V. De Francesco, M. Menegatti, A. Tampieri, F. Perna, V. Rinaldi, F. Perri, C. Papadìa, F. Fornari, S. Pilati, L. S. Mete, A. Merla, R. Potì, G. Marinone, A. SavioliS. M A Campo, D. Faleo, E. Ierardi, M. Miglioli, S. Morini

Research output: Contribution to journalArticle

Abstract

Background: Eradication rates of Helicobacter pylori with standard triple therapy are disappointing, and studies from several countries confirm this poor performance. Aim: To assess the eradication rate of a new sequential treatment regimen compared with conventional triple therapy for the eradication of H. pylori infection. Methods: One thousand and forty-nine dyspeptic patients were studied prospectively. H. pylori-infected patients were randomized to receive 10-day sequential therapy [rabeprazole (40 mg daily) plus amoxicillin (1 g twice daily) for the first 5 days, followed by rabeprazole (20 mg), clarithromycin (500 mg) and tinidazole (500 mg) twice daily for the remaining 5 days] or standard 7-day treatment [rabeprazole (20 mg), clarithromycin (500 mg) and amoxicillin (1 g) twice daily]. H. pylori status was assessed by histology, rapid urease test and 13C-urea breath test at baseline and 6 weeks or more after completion of treatment. Results: Higher eradication rates were found with the sequential regimen compared to the standard regimen (intention-to-treat: 92% vs. 74%, P <0.0001; per protocol: 95% vs. 77%, P <0.0001). Higher eradication rates were also seen in patients with peptic ulcer disease and non-ulcer dyspepsia. In both treatments, compliance was similar (> 90%), as was the rate of side-effects, which were mild. Conclusions: This 10-day sequential treatment regimen achieves high eradication rates in peptic ulcer disease and non-ulcer dyspepsia.

Original languageEnglish
Pages (from-to)719-726
Number of pages8
JournalAlimentary Pharmacology and Therapeutics
Volume17
Issue number5
DOIs
Publication statusPublished - Mar 1 2003

ASJC Scopus subject areas

  • Pharmacology (medical)
  • Pharmacology, Toxicology and Pharmaceutics(all)

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    Zullo, A., Vaira, D., Vakil, N., Hassan, C., Gatta, L., Ricci, C., De Francesco, V., Menegatti, M., Tampieri, A., Perna, F., Rinaldi, V., Perri, F., Papadìa, C., Fornari, F., Pilati, S., Mete, L. S., Merla, A., Potì, R., Marinone, G., ... Morini, S. (2003). High eradication rates of Helicobacter pylori with a new sequential treatment. Alimentary Pharmacology and Therapeutics, 17(5), 719-726. https://doi.org/10.1046/j.1365-2036.2003.01461.x