Abstract
The exact prevalence and pathogenic role of antiphospholipid antibodies (aPL) in multiple sclerosis (MS) remain unclear. This observational laboratory-blinded study evaluated the rate of aPL positivity in healthy controls and MS patients in different disease phases to recognize their frequency and possible pathogenic meaning. Reactivity for anti-cardiolipin, anti-β2 glycoprotein I, anti-prothrombin, anti-annexin V (IgG and IgM) was studied by enzyme immunoassays in 60 healthy controls and 100 consecutive MS patients [58 relapsing–remitting (RR) patients in remission, 26 RR patients in relapse, and 16 secondary progressive patients]. The overall rate of positivity for at least one aPL was significantly higher in MS patients compared to controls (32 % vs. 7 %, respectively, p
| Original language | English |
|---|---|
| Pages (from-to) | 1737-1741 |
| Number of pages | 5 |
| Journal | Neurological Sciences |
| Volume | 35 |
| Issue number | 11 |
| DOIs | |
| Publication status | Published - 2014 |
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Keywords
- Antiphospholipid antibodies
- Beta 2-glycoprotein-I
- Multiple Sclerosis
- Prothrombin
- Relapse
ASJC Scopus subject areas
- Clinical Neurology
- Psychiatry and Mental health
- Dermatology
Cite this
High frequency of antiphospholipid antibodies in relapse of multiple sclerosis : a possible indicator of inflammatory–thrombotic processes. / Koudriavtseva, Tatiana; D’Agosto, Giovanna; Mandoj, Chiara; Sperduti, Isabella; Cordiali-Fei, Paola.
In: Neurological Sciences, Vol. 35, No. 11, 2014, p. 1737-1741.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - High frequency of antiphospholipid antibodies in relapse of multiple sclerosis
T2 - a possible indicator of inflammatory–thrombotic processes
AU - Koudriavtseva, Tatiana
AU - D’Agosto, Giovanna
AU - Mandoj, Chiara
AU - Sperduti, Isabella
AU - Cordiali-Fei, Paola
PY - 2014
Y1 - 2014
N2 - The exact prevalence and pathogenic role of antiphospholipid antibodies (aPL) in multiple sclerosis (MS) remain unclear. This observational laboratory-blinded study evaluated the rate of aPL positivity in healthy controls and MS patients in different disease phases to recognize their frequency and possible pathogenic meaning. Reactivity for anti-cardiolipin, anti-β2 glycoprotein I, anti-prothrombin, anti-annexin V (IgG and IgM) was studied by enzyme immunoassays in 60 healthy controls and 100 consecutive MS patients [58 relapsing–remitting (RR) patients in remission, 26 RR patients in relapse, and 16 secondary progressive patients]. The overall rate of positivity for at least one aPL was significantly higher in MS patients compared to controls (32 % vs. 7 %, respectively, p
AB - The exact prevalence and pathogenic role of antiphospholipid antibodies (aPL) in multiple sclerosis (MS) remain unclear. This observational laboratory-blinded study evaluated the rate of aPL positivity in healthy controls and MS patients in different disease phases to recognize their frequency and possible pathogenic meaning. Reactivity for anti-cardiolipin, anti-β2 glycoprotein I, anti-prothrombin, anti-annexin V (IgG and IgM) was studied by enzyme immunoassays in 60 healthy controls and 100 consecutive MS patients [58 relapsing–remitting (RR) patients in remission, 26 RR patients in relapse, and 16 secondary progressive patients]. The overall rate of positivity for at least one aPL was significantly higher in MS patients compared to controls (32 % vs. 7 %, respectively, p
KW - Antiphospholipid antibodies
KW - Beta 2-glycoprotein-I
KW - Multiple Sclerosis
KW - Prothrombin
KW - Relapse
UR - http://www.scopus.com/inward/record.url?scp=84939871590&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84939871590&partnerID=8YFLogxK
U2 - 10.1007/s10072-014-1823-4
DO - 10.1007/s10072-014-1823-4
M3 - Article
C2 - 24847961
AN - SCOPUS:84939871590
VL - 35
SP - 1737
EP - 1741
JO - Neurological Sciences
JF - Neurological Sciences
SN - 1590-1874
IS - 11
ER -