TY - JOUR
T1 - High frequency of antiphospholipid antibodies in relapse of multiple sclerosis
T2 - a possible indicator of inflammatory–thrombotic processes
AU - Koudriavtseva, Tatiana
AU - D’Agosto, Giovanna
AU - Mandoj, Chiara
AU - Sperduti, Isabella
AU - Cordiali-Fei, Paola
PY - 2014
Y1 - 2014
N2 - The exact prevalence and pathogenic role of antiphospholipid antibodies (aPL) in multiple sclerosis (MS) remain unclear. This observational laboratory-blinded study evaluated the rate of aPL positivity in healthy controls and MS patients in different disease phases to recognize their frequency and possible pathogenic meaning. Reactivity for anti-cardiolipin, anti-β2 glycoprotein I, anti-prothrombin, anti-annexin V (IgG and IgM) was studied by enzyme immunoassays in 60 healthy controls and 100 consecutive MS patients [58 relapsing–remitting (RR) patients in remission, 26 RR patients in relapse, and 16 secondary progressive patients]. The overall rate of positivity for at least one aPL was significantly higher in MS patients compared to controls (32 % vs. 7 %, respectively, p
AB - The exact prevalence and pathogenic role of antiphospholipid antibodies (aPL) in multiple sclerosis (MS) remain unclear. This observational laboratory-blinded study evaluated the rate of aPL positivity in healthy controls and MS patients in different disease phases to recognize their frequency and possible pathogenic meaning. Reactivity for anti-cardiolipin, anti-β2 glycoprotein I, anti-prothrombin, anti-annexin V (IgG and IgM) was studied by enzyme immunoassays in 60 healthy controls and 100 consecutive MS patients [58 relapsing–remitting (RR) patients in remission, 26 RR patients in relapse, and 16 secondary progressive patients]. The overall rate of positivity for at least one aPL was significantly higher in MS patients compared to controls (32 % vs. 7 %, respectively, p
KW - Antiphospholipid antibodies
KW - Beta 2-glycoprotein-I
KW - Multiple Sclerosis
KW - Prothrombin
KW - Relapse
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U2 - 10.1007/s10072-014-1823-4
DO - 10.1007/s10072-014-1823-4
M3 - Article
C2 - 24847961
AN - SCOPUS:84939871590
VL - 35
SP - 1737
EP - 1741
JO - Neurological Sciences
JF - Neurological Sciences
SN - 1590-1874
IS - 11
ER -