High frequency of c-k-ras activation in 3-methylcholanthrene-induced mouse thymomas

Alessandra Eva, Roy W. Trimmer

Research output: Contribution to journalArticle


Thymic lymphomas were induced in RJF mice by percutaneous application of 3-methykholanthrene (MCA). DNAs from 83% of the tumors analyzed contained a transforming c-K-ras gene. The high frequency of c-K-ras oncogene activation in response to MCA seems to favor the concept that the activation of c-K-ras is related to the specificity of the mutagenic effect of MCA.

Original languageEnglish
Pages (from-to)1931-1933
Number of pages3
Issue number11
Publication statusPublished - Nov 1986


ASJC Scopus subject areas

  • Statistics, Probability and Uncertainty
  • Applied Mathematics
  • Physiology (medical)
  • Physiology
  • Behavioral Neuroscience
  • Cancer Research

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