High frequency of CD45RO expression in AIDS-related B-cell non-Hodgkin's lymphomas

A. Gloghini, P. De Paoli, G. Gaidano, S. Franceschi, A. Carbone

Research output: Contribution to journalArticle

Abstract

Although immunophenotypic abnormalities have been reported in B-cell non- Hodgkin's lymphomas (NHLs) occurring in the general population, there are no extensive studies on such abnormalities in AIDS-related B-cell NHLs. Reactivity of CD45RO/UCHL1 and expression of other T-cell associated antigens (CD43, OPD4, CD3, CD5, EMA) were examined by immunohistochemistry in 66 diffuse aggressive AIDS-related B-cell NHLs and in 296 AIDS-unrelated B-cell NHLs of similar morphology analyzed in the same institution. EBER in situ hybridization studies were also carried out in 57 of the 66 AIDS-related B- cell NHLs investigated. CD45RO/UCHL1 was expressed in 27% of AIDS-related B- cell NHLs, but only in 8% of diffuse aggressive AIDS-unrelated B-cell NHLs. The difference was highly significant (P

Original languageEnglish
Pages (from-to)680-688
Number of pages9
JournalAmerican Journal of Clinical Pathology
Volume104
Issue number6
Publication statusPublished - 1995

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Keywords

  • AIDS-related B-cell lymphomas
  • CD45RO/UCHLI
  • Immunohistochemistry
  • Immunophenotypic abnormality
  • Non-Hodgkin's lymphomas

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

Cite this

Gloghini, A., De Paoli, P., Gaidano, G., Franceschi, S., & Carbone, A. (1995). High frequency of CD45RO expression in AIDS-related B-cell non-Hodgkin's lymphomas. American Journal of Clinical Pathology, 104(6), 680-688.