High frequency of clonal immunoglobulin or T cell receptor gene rearrangements in acute myelogenous leukemia expressing terminal deoxyribonucleotidyltransferase

S. V. Seremetis, P. G. Pelicci, A. Tabilio, A. Ubriaco, F. Grignani, J. Cuttner, R. J. Winchester, D. M. Knowles, R. Dalla-Favera

Research output: Contribution to journalArticlepeer-review

Abstract

Ig and T cell receptor rearrangements have been used as irreversible markers of lineage and clonality in the study of B- and T-lymphoid populations. We have addressed the issue of lymphoid lineage specificity of these rearrangements by analyzing a panel of 25 TdT- acute myelogenous leukemias, 13 TdT+ AMLs, and 4 TdT+ undifferentiated leukemias. We report that while gene rearrangements represent extremely rare events in classical TdT- AML (<8%), rearrangements of either the Ig or T(β) locus or both were detectable in the majority of the TdT+ AMLs (> 60%), and rearrangements of both loci were detectable in all of the TdT+ undifferentiated leukemias. These data demonstrate a significant association between TdT expression and Ig or T(β) gene rearrangements even outside the lymphoid lineage, further supporting a role for TdT in Ig and T cell receptor gene assembly. These data also indicate that a coordinated program of lymphoid gene expression involving TdT-CD7-expression and Ig/T(β) rearrangements can be activated before myeloid commitment. Whether the activation of this program represents a normal, albeit rate, event in early myelopoiesis or a transformation-related event present only in leukemic cells remains to be determined.

Original languageEnglish
Pages (from-to)1703-1712
Number of pages10
JournalJournal of Experimental Medicine
Volume165
Issue number6
DOIs
Publication statusPublished - 1987

ASJC Scopus subject areas

  • Immunology

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