High frequency of human papillomavirus detection in urinary bladder cancer

Anna Maria Aglianò, Angela Gradilone, Paola Gazzaniga, Maria Napolitano, Roberta Vercillo, Loredana Albonici, Giuseppe Naso, Vittorio Manzari, Luigi Frati, Aldo Vecchione

Research output: Contribution to journalArticle

Abstract

We investigated the presence of human papillomaviruses (HPVs) types 16 and 18 DNA in formalin-fixed, paraffin-embedded tissues from the urinary bladder (46 transitional carcinomas and 10 non-neoplastic normal urinary samples) to find a possible role for HPV types in urinary tract cancerogenesis. The analysis was performed using polymerase chain reaction followed by filter hybridization with oligonucleotide-specific probes. The HPV 16 and/or HPV18 genomes were detected in 23 of 46 (50%) bladder carcinomas and in none of 10 (0%) non-neoplastic urinary samples. These results suggest that HPV 16 and 18 may carry a risk for the development of malignancy in the urinary tract as it occurs in the anogenital regions.

Original languageEnglish
Pages (from-to)125-129
Number of pages5
JournalUrologia Internationalis
Volume53
Issue number3
DOIs
Publication statusPublished - 1994

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Human papillomavirus 16
Urinary Bladder Neoplasms
Human papillomavirus 18
Urinary Tract
Urinary Bladder
Carcinoma
Oligonucleotide Probes
Paraffin
Formaldehyde
Genome
Polymerase Chain Reaction
DNA
Neoplasms

Keywords

  • Papillomavirus, Human Carcinoma
  • Polymerase chain reaction

ASJC Scopus subject areas

  • Urology

Cite this

Aglianò, A. M., Gradilone, A., Gazzaniga, P., Napolitano, M., Vercillo, R., Albonici, L., ... Vecchione, A. (1994). High frequency of human papillomavirus detection in urinary bladder cancer. Urologia Internationalis, 53(3), 125-129. https://doi.org/10.1159/000282652

High frequency of human papillomavirus detection in urinary bladder cancer. / Aglianò, Anna Maria; Gradilone, Angela; Gazzaniga, Paola; Napolitano, Maria; Vercillo, Roberta; Albonici, Loredana; Naso, Giuseppe; Manzari, Vittorio; Frati, Luigi; Vecchione, Aldo.

In: Urologia Internationalis, Vol. 53, No. 3, 1994, p. 125-129.

Research output: Contribution to journalArticle

Aglianò, AM, Gradilone, A, Gazzaniga, P, Napolitano, M, Vercillo, R, Albonici, L, Naso, G, Manzari, V, Frati, L & Vecchione, A 1994, 'High frequency of human papillomavirus detection in urinary bladder cancer', Urologia Internationalis, vol. 53, no. 3, pp. 125-129. https://doi.org/10.1159/000282652
Aglianò AM, Gradilone A, Gazzaniga P, Napolitano M, Vercillo R, Albonici L et al. High frequency of human papillomavirus detection in urinary bladder cancer. Urologia Internationalis. 1994;53(3):125-129. https://doi.org/10.1159/000282652
Aglianò, Anna Maria ; Gradilone, Angela ; Gazzaniga, Paola ; Napolitano, Maria ; Vercillo, Roberta ; Albonici, Loredana ; Naso, Giuseppe ; Manzari, Vittorio ; Frati, Luigi ; Vecchione, Aldo. / High frequency of human papillomavirus detection in urinary bladder cancer. In: Urologia Internationalis. 1994 ; Vol. 53, No. 3. pp. 125-129.
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