High frequency of micronuclei in peripheral blood lymphocytes as index of susceptibility to pleural malignant mesothelioma

Claudia Bolognesi, Rosangela Filiberti, Monica Neri, Emanuela Perrone, Eleonora Landini, Pier Aldo Canessa, Claudio Simonassi, Paolo Giuseppe Cerrano, Luciano Mutti, Riccardo Puntoni

Research output: Contribution to journalArticlepeer-review

Abstract

We evaluated the frequency of micronuclei (MN) in peripheral blood lymphocytes of patients with pleural malignant mesotelioma (MM), lung cancer, benign respiratory diseases, and healthy controls. A significant increased frequency of MN was observed in patients with MM in comparison with all the other groups (median, 11.4 binucleated MN/1000 binucleated cells versus 5.1, 6.1, and 6.2, respectively). No association was found between MN and asbestos exposure. Recently, genetic susceptibility associated with asbestos exposure has been recognized in the development of MM. The presence of high frequency of MN in peripheral blood lymphocytes of patients with MM could represent a useful index of individual susceptibility to this tumor.

Original languageEnglish
Pages (from-to)5418-5419
Number of pages2
JournalCancer Research
Volume62
Issue number19
Publication statusPublished - Oct 1 2002

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

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