Abstract
The human basal ganglia, and in particular the subthalamic nucleus (STN), can oscillate at surprisingly high frequencies, around 300 Hz [G. Foffani, A. Priori, M. Egidi, P. Rampini, F. Tamma, E. Caputo, K.A. Moxon, S. Cerutti, S. Barbieri, 300-Hz subthalamic oscillations in Parkinson's disease, Brain 126 (2003) 2153-2163]. It has been proposed that these oscillations could contribute to the mechanisms of action of deep brain stimulation (DBS) [G. Foffani, A. Priori, Deep brain stimulation in Parkinson's disease can mimic the 300 Hz subthalamic rhythm, Brain 129 (2006) E59]. However, the physiological role of high-frequency STN oscillations is questionable, because they have been observed only in patients with advanced Parkinson's disease and could therefore be secondary to the dopamine-depleted parkinsonian state. Here, we report high-frequency STN oscillations in the range of the 300-Hz rhythm during intraoperative microrecordings for DBS in an awake patient with focal dystonia as well as in a patient with essential tremor (ET). High-frequency STN oscillations are therefore not exclusively related to parkinsonian pathophysiology, but may represent a broader feature of human STN function.
| Original language | English |
|---|---|
| Pages (from-to) | 84-90 |
| Number of pages | 7 |
| Journal | Brain Research Bulletin |
| Volume | 74 |
| Issue number | 1-3 |
| DOIs | |
| Publication status | Published - Sep 14 2007 |
Fingerprint
Keywords
- DBS
- Deep brain stimulation
- High-frequency oscillations
- Human
- STN
- Subthalamic nucleus
ASJC Scopus subject areas
- Neuroscience(all)
Cite this
High-frequency oscillations (>200 Hz) in the human non-parkinsonian subthalamic nucleus. / Danish, S. F.; Moyer, J. T.; Finkel, L. H.; Baltuch, G. H.; Jaggi, J. L.; Priori, A.; Foffani, G.
In: Brain Research Bulletin, Vol. 74, No. 1-3, 14.09.2007, p. 84-90.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - High-frequency oscillations (>200 Hz) in the human non-parkinsonian subthalamic nucleus
AU - Danish, S. F.
AU - Moyer, J. T.
AU - Finkel, L. H.
AU - Baltuch, G. H.
AU - Jaggi, J. L.
AU - Priori, A.
AU - Foffani, G.
PY - 2007/9/14
Y1 - 2007/9/14
N2 - The human basal ganglia, and in particular the subthalamic nucleus (STN), can oscillate at surprisingly high frequencies, around 300 Hz [G. Foffani, A. Priori, M. Egidi, P. Rampini, F. Tamma, E. Caputo, K.A. Moxon, S. Cerutti, S. Barbieri, 300-Hz subthalamic oscillations in Parkinson's disease, Brain 126 (2003) 2153-2163]. It has been proposed that these oscillations could contribute to the mechanisms of action of deep brain stimulation (DBS) [G. Foffani, A. Priori, Deep brain stimulation in Parkinson's disease can mimic the 300 Hz subthalamic rhythm, Brain 129 (2006) E59]. However, the physiological role of high-frequency STN oscillations is questionable, because they have been observed only in patients with advanced Parkinson's disease and could therefore be secondary to the dopamine-depleted parkinsonian state. Here, we report high-frequency STN oscillations in the range of the 300-Hz rhythm during intraoperative microrecordings for DBS in an awake patient with focal dystonia as well as in a patient with essential tremor (ET). High-frequency STN oscillations are therefore not exclusively related to parkinsonian pathophysiology, but may represent a broader feature of human STN function.
AB - The human basal ganglia, and in particular the subthalamic nucleus (STN), can oscillate at surprisingly high frequencies, around 300 Hz [G. Foffani, A. Priori, M. Egidi, P. Rampini, F. Tamma, E. Caputo, K.A. Moxon, S. Cerutti, S. Barbieri, 300-Hz subthalamic oscillations in Parkinson's disease, Brain 126 (2003) 2153-2163]. It has been proposed that these oscillations could contribute to the mechanisms of action of deep brain stimulation (DBS) [G. Foffani, A. Priori, Deep brain stimulation in Parkinson's disease can mimic the 300 Hz subthalamic rhythm, Brain 129 (2006) E59]. However, the physiological role of high-frequency STN oscillations is questionable, because they have been observed only in patients with advanced Parkinson's disease and could therefore be secondary to the dopamine-depleted parkinsonian state. Here, we report high-frequency STN oscillations in the range of the 300-Hz rhythm during intraoperative microrecordings for DBS in an awake patient with focal dystonia as well as in a patient with essential tremor (ET). High-frequency STN oscillations are therefore not exclusively related to parkinsonian pathophysiology, but may represent a broader feature of human STN function.
KW - DBS
KW - Deep brain stimulation
KW - High-frequency oscillations
KW - Human
KW - STN
KW - Subthalamic nucleus
UR - http://www.scopus.com/inward/record.url?scp=34547561092&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=34547561092&partnerID=8YFLogxK
U2 - 10.1016/j.brainresbull.2007.05.006
DO - 10.1016/j.brainresbull.2007.05.006
M3 - Article
C2 - 17683793
AN - SCOPUS:34547561092
VL - 74
SP - 84
EP - 90
JO - Brain Research Bulletin
JF - Brain Research Bulletin
SN - 0361-9230
IS - 1-3
ER -