High frequency somatosensory stimulation increases sensori-motor inhibition and leads to perceptual improvement in healthy subjects

Lorenzo Rocchi, Roberto Erro, Elena Antelmi, Alfredo Berardelli, Michele Tinazzi, Rocco Liguori, Kailash P. Bhatia, John Rothwell

Research output: Contribution to journalArticlepeer-review

Abstract

Objective High frequency repetitive somatosensory stimulation (HF-RSS), which is a patterned electric stimulation applied to the skin through surface electrodes, improves two-point discrimination, somatosensory temporal discrimination threshold (STDT) and motor performance in humans. However, the mechanisms which underlie these changes are still unknown. In particular, we hypothesize that refinement of inhibition might be responsible for the improvement in spatial and temporal perception. Methods Fifteen healthy subjects underwent 45 min of HF-RSS. Before and after the intervention several measures of inhibition in the primary somatosensory area (S1), such as paired-pulse somatosensory evoked potentials (pp-SEP), high-frequency oscillations (HFO), and STDT were tested, as well as tactile spatial acuity and short intracortical inhibition (SICI). Results HF-RSS increased inhibition in S1 tested by pp-SEP and HFO; these changes were correlated with improvement in STDT. HF-RSS also enhanced bumps detection, while there was no change in grating orientation test. Finally there was an increase in SICI, suggesting widespread changes in cortical sensorimotor interactions. Conclusions These findings suggest that HF-RSS can improve spatial and temporal tactile abilities by increasing the effectiveness of inhibitory interactions in the somatosensory system. Moreover, HF-RSS induces changes in cortical sensorimotor interaction. Significance HF-RSS is a repetitive electric stimulation technique able to modify the effectiveness of inhibitory circuitry in the somatosensory system and primary motor cortex.

Original languageEnglish
Pages (from-to)1015-1025
Number of pages11
JournalClinical Neurophysiology
Volume128
Issue number6
DOIs
Publication statusPublished - Jun 1 2017

Keywords

  • Cortical inhibition
  • Evoked potentials
  • High frequency oscillations
  • Tactile stimulation
  • Temporal discrimination
  • Transcranial magnetic stimulation

ASJC Scopus subject areas

  • Sensory Systems
  • Neurology
  • Clinical Neurology
  • Physiology (medical)

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