High frequency stimulation of the subthalamic nucleus is efficacious in Parkin disease

L. M A Romito, Maria F. Contarino, Daniele Ghezzi, Angelo Franzini, Barbara Garavaglia, Alberto Albanese

Research output: Contribution to journalArticlepeer-review

Abstract

High frequency stimulation (HFS) of the subthalamic nucleus (STN) is an efficacious symptomatic treatment for Parkinson's disease. We have analysed the genetic status of a series of consecutive parkinsonian patients implanted for STN HFS and compared the outcome of five carrying mutations in the parkin gene with that of the non-parkin group. All patients obtained sustained control of PD symptoms and achieved functional improvement; in the parkin group the UPDRS motor score improved by 56.4%, the levodopa equivalent daily dosage was reduced by 75.5%. Postoperative medications were reduced more in parkin than in non-parkin patients. We confirm that the current inclusion criteria for STN HFS do not exclude patients carrying mutations in the parkin gene; their clinical outcome is comparable to that of the non-parkin group.

Original languageEnglish
Pages (from-to)208-211
Number of pages4
JournalJournal of Neurology
Volume252
Issue number2
DOIs
Publication statusPublished - Feb 2005

Keywords

  • Deep brain stimulation
  • Neurostimulation
  • PARK2
  • Parkin disease
  • Parkinson's disease
  • Subthalamic stimulation
  • Surgery

ASJC Scopus subject areas

  • Clinical Neurology
  • Neurology

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