High frequency stimulation of the subthalamic nucleus is efficacious in Parkin disease

L. M A Romito; Maria F. Contarino; Daniele Ghezzi; Angelo Franzini; Barbara Garavaglia; Alberto Albanese

doi:10.1007/s00415-005-0638-x

High frequency stimulation of the subthalamic nucleus is efficacious in Parkin disease

L. M A Romito, Maria F. Contarino, Daniele Ghezzi, Angelo Franzini, Barbara Garavaglia, Alberto Albanese

Fondazione IRCCS Istituto Neurologico "C. Besta"

Research output: Contribution to journal › Article › peer-review

Abstract

High frequency stimulation (HFS) of the subthalamic nucleus (STN) is an efficacious symptomatic treatment for Parkinson's disease. We have analysed the genetic status of a series of consecutive parkinsonian patients implanted for STN HFS and compared the outcome of five carrying mutations in the parkin gene with that of the non-parkin group. All patients obtained sustained control of PD symptoms and achieved functional improvement; in the parkin group the UPDRS motor score improved by 56.4%, the levodopa equivalent daily dosage was reduced by 75.5%. Postoperative medications were reduced more in parkin than in non-parkin patients. We confirm that the current inclusion criteria for STN HFS do not exclude patients carrying mutations in the parkin gene; their clinical outcome is comparable to that of the non-parkin group.

Original language	English
Pages (from-to)	208-211
Number of pages	4
Journal	Journal of Neurology
Volume	252
Issue number	2
DOIs	https://doi.org/10.1007/s00415-005-0638-x
Publication status	Published - Feb 2005

Keywords

Deep brain stimulation
Neurostimulation
PARK2
Parkin disease
Parkinson's disease
Subthalamic stimulation
Surgery

ASJC Scopus subject areas

Clinical Neurology
Neurology

Access to Document

10.1007/s00415-005-0638-x

Fingerprint Dive into the research topics of 'High frequency stimulation of the subthalamic nucleus is efficacious in Parkin disease'. Together they form a unique fingerprint.

Cite this

@article{abd5d9f7096b442fb55182c3a89170e5,

title = "High frequency stimulation of the subthalamic nucleus is efficacious in Parkin disease",

abstract = "High frequency stimulation (HFS) of the subthalamic nucleus (STN) is an efficacious symptomatic treatment for Parkinson's disease. We have analysed the genetic status of a series of consecutive parkinsonian patients implanted for STN HFS and compared the outcome of five carrying mutations in the parkin gene with that of the non-parkin group. All patients obtained sustained control of PD symptoms and achieved functional improvement; in the parkin group the UPDRS motor score improved by 56.4%, the levodopa equivalent daily dosage was reduced by 75.5%. Postoperative medications were reduced more in parkin than in non-parkin patients. We confirm that the current inclusion criteria for STN HFS do not exclude patients carrying mutations in the parkin gene; their clinical outcome is comparable to that of the non-parkin group.",

keywords = "Deep brain stimulation, Neurostimulation, PARK2, Parkin disease, Parkinson's disease, Subthalamic stimulation, Surgery",

author = "Romito, {L. M A} and Contarino, {Maria F.} and Daniele Ghezzi and Angelo Franzini and Barbara Garavaglia and Alberto Albanese",

year = "2005",

month = feb,

doi = "10.1007/s00415-005-0638-x",

language = "English",

volume = "252",

pages = "208--211",

journal = "Journal of Neurology",

issn = "0340-5354",

publisher = "Dr. Dietrich Steinkopff Verlag GmbH and Co. KG",

number = "2",

}

TY - JOUR

T1 - High frequency stimulation of the subthalamic nucleus is efficacious in Parkin disease

AU - Romito, L. M A

AU - Contarino, Maria F.

AU - Ghezzi, Daniele

AU - Franzini, Angelo

AU - Garavaglia, Barbara

AU - Albanese, Alberto

PY - 2005/2

Y1 - 2005/2

N2 - High frequency stimulation (HFS) of the subthalamic nucleus (STN) is an efficacious symptomatic treatment for Parkinson's disease. We have analysed the genetic status of a series of consecutive parkinsonian patients implanted for STN HFS and compared the outcome of five carrying mutations in the parkin gene with that of the non-parkin group. All patients obtained sustained control of PD symptoms and achieved functional improvement; in the parkin group the UPDRS motor score improved by 56.4%, the levodopa equivalent daily dosage was reduced by 75.5%. Postoperative medications were reduced more in parkin than in non-parkin patients. We confirm that the current inclusion criteria for STN HFS do not exclude patients carrying mutations in the parkin gene; their clinical outcome is comparable to that of the non-parkin group.

AB - High frequency stimulation (HFS) of the subthalamic nucleus (STN) is an efficacious symptomatic treatment for Parkinson's disease. We have analysed the genetic status of a series of consecutive parkinsonian patients implanted for STN HFS and compared the outcome of five carrying mutations in the parkin gene with that of the non-parkin group. All patients obtained sustained control of PD symptoms and achieved functional improvement; in the parkin group the UPDRS motor score improved by 56.4%, the levodopa equivalent daily dosage was reduced by 75.5%. Postoperative medications were reduced more in parkin than in non-parkin patients. We confirm that the current inclusion criteria for STN HFS do not exclude patients carrying mutations in the parkin gene; their clinical outcome is comparable to that of the non-parkin group.

KW - Deep brain stimulation

KW - Neurostimulation

KW - PARK2

KW - Parkin disease

KW - Parkinson's disease

KW - Subthalamic stimulation

KW - Surgery

UR - http://www.scopus.com/inward/record.url?scp=15244344961&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=15244344961&partnerID=8YFLogxK

U2 - 10.1007/s00415-005-0638-x

DO - 10.1007/s00415-005-0638-x

M3 - Article

C2 - 15729528

AN - SCOPUS:15244344961

VL - 252

SP - 208

EP - 211

JO - Journal of Neurology

JF - Journal of Neurology

SN - 0340-5354

IS - 2

ER -