High grade prostatic intraepithelial neoplasia with squamous differentiation

M. Melissari, A. Lopez Beltran, R. Mazzucchelli, E. Froio, D. G. Bostwick, R. Montironi, Rodolfo Montironi

Research output: Contribution to journalArticlepeer-review


An unusual variant of prostatic intraepithelial neoplasia with prominent and extensive squamous differentiation is described. The lesion was identified in the transition zone of a 79 year old man with a three year history of increasing urinary obstructive symptoms and a clinical diagnosis of benign prostatic hyperplasia who underwent simple prostatectomy. Two years after surgery, prostatic biopsies showed atrophy and mild chronic inflammation, with no evidence of malignancy. This unusual introepithelial lesion seems not to have been described before and may represent a new variant of high grade prostatic intraepithelial neoplasia (HGPIN) with squamous differentiation.

Original languageEnglish
Pages (from-to)437-439
Number of pages3
JournalJournal of Clinical Pathology
Issue number4
Publication statusPublished - Apr 2006

ASJC Scopus subject areas

  • Pathology and Forensic Medicine


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