High-grade vaginal intraepithelial neoplasia and risk of progression to vaginal cancer: a multicentre study of the Italian Society of Colposcopy and Cervico-Vaginal Pathology (SICPCV)

F Sopracordevole, M. Barbero, Nausicaa Clemente, M. G. Fallani, P. Cattani, A. Agarossi, G. De Piero, A. Parin, A. Frega, F. Boselli, Francesca Mancioli, M Buttignol, Francesca Currado, A. L. Pieralli, A. Ciavattini, Italian Society of Colposcopy and Cervico-Vaginal Pathology (SICPCV)

Research output: Contribution to journalArticle

Abstract

OBJECTIVE: The aim of this study was to analyse the women with high grade vaginal intraepithelial neoplasia (HG-VaIN), in order to identify a subset of women at higher risk of progression to invasive vaginal cancer.

MATERIALS AND METHODS: The medical records of all the women diagnosed with HG-VaIN, and subsequently treated, from January 1995 to December 2013 were analyzed in a multicentre retrospective case series. The rate of progression to invasive vaginal cancer and the potential risk factors were evaluated.

RESULTS: 205 women with biopsy diagnosis of HG-VaIN were considered, with a mean follow up of 57 months (range 4-254 months). 12 cases of progression to vaginal squamocellular cancer were observed (5.8%), with a mean time interval from treatment to progression of 54.6 months (range 4-146 months). The rate of progression was significantly higher in women diagnosed with VaIN3 compared with VaIN2 (15.4% vs. 1.4%, p < 0.0001). Women with HG-VaIN and with previous hysterectomy showed a significantly higher rate of progression to invasive vaginal cancer compared to non-hysterectomised women (16.7% vs. 1.4%, p < 0.0001). A higher risk of progression for women with VaIN3 and for women with previous hysterectomy for cervical HPV-related disease was confirmed by multivariable logistic regression analysis.

CONCLUSIONS: A higher rate of progression to vaginal cancer was reported in women diagnosed with VaIN3 on biopsy and in women with previous hysterectomy for HPV-related cervical disease. These patients should be considered at higher risk, thus a long lasting and accurate follow up is recommended.

Original languageEnglish
Pages (from-to)818-24
Number of pages7
JournalEuropean Review for Medical and Pharmacological Sciences
Volume20
Issue number5
Publication statusPublished - Mar 2016

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Vaginal Neoplasms
Colposcopy
Multicenter Studies
Pathology
Neoplasms
Hysterectomy
Biopsy
Medical Records

Keywords

  • Adult
  • Aged
  • Carcinoma in Situ
  • Colposcopy
  • Disease Progression
  • Female
  • Follow-Up Studies
  • Humans
  • Italy
  • Middle Aged
  • Neoplasm Grading
  • Pregnancy
  • Retrospective Studies
  • Risk Factors
  • Vaginal Neoplasms
  • Journal Article
  • Multicenter Study

Cite this

Sopracordevole, F., Barbero, M., Clemente, N., Fallani, M. G., Cattani, P., Agarossi, A., ... Italian Society of Colposcopy and Cervico-Vaginal Pathology (SICPCV) (2016). High-grade vaginal intraepithelial neoplasia and risk of progression to vaginal cancer: a multicentre study of the Italian Society of Colposcopy and Cervico-Vaginal Pathology (SICPCV). European Review for Medical and Pharmacological Sciences, 20(5), 818-24.

High-grade vaginal intraepithelial neoplasia and risk of progression to vaginal cancer : a multicentre study of the Italian Society of Colposcopy and Cervico-Vaginal Pathology (SICPCV). / Sopracordevole, F; Barbero, M.; Clemente, Nausicaa; Fallani, M. G.; Cattani, P.; Agarossi, A.; De Piero, G.; Parin, A.; Frega, A.; Boselli, F.; Mancioli, Francesca; Buttignol, M; Currado, Francesca; Pieralli, A. L.; Ciavattini, A.; Italian Society of Colposcopy and Cervico-Vaginal Pathology (SICPCV).

In: European Review for Medical and Pharmacological Sciences, Vol. 20, No. 5, 03.2016, p. 818-24.

Research output: Contribution to journalArticle

Sopracordevole, F, Barbero, M, Clemente, N, Fallani, MG, Cattani, P, Agarossi, A, De Piero, G, Parin, A, Frega, A, Boselli, F, Mancioli, F, Buttignol, M, Currado, F, Pieralli, AL, Ciavattini, A & Italian Society of Colposcopy and Cervico-Vaginal Pathology (SICPCV) 2016, 'High-grade vaginal intraepithelial neoplasia and risk of progression to vaginal cancer: a multicentre study of the Italian Society of Colposcopy and Cervico-Vaginal Pathology (SICPCV)', European Review for Medical and Pharmacological Sciences, vol. 20, no. 5, pp. 818-24.
Sopracordevole, F ; Barbero, M. ; Clemente, Nausicaa ; Fallani, M. G. ; Cattani, P. ; Agarossi, A. ; De Piero, G. ; Parin, A. ; Frega, A. ; Boselli, F. ; Mancioli, Francesca ; Buttignol, M ; Currado, Francesca ; Pieralli, A. L. ; Ciavattini, A. ; Italian Society of Colposcopy and Cervico-Vaginal Pathology (SICPCV). / High-grade vaginal intraepithelial neoplasia and risk of progression to vaginal cancer : a multicentre study of the Italian Society of Colposcopy and Cervico-Vaginal Pathology (SICPCV). In: European Review for Medical and Pharmacological Sciences. 2016 ; Vol. 20, No. 5. pp. 818-24.
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abstract = "OBJECTIVE: The aim of this study was to analyse the women with high grade vaginal intraepithelial neoplasia (HG-VaIN), in order to identify a subset of women at higher risk of progression to invasive vaginal cancer.MATERIALS AND METHODS: The medical records of all the women diagnosed with HG-VaIN, and subsequently treated, from January 1995 to December 2013 were analyzed in a multicentre retrospective case series. The rate of progression to invasive vaginal cancer and the potential risk factors were evaluated.RESULTS: 205 women with biopsy diagnosis of HG-VaIN were considered, with a mean follow up of 57 months (range 4-254 months). 12 cases of progression to vaginal squamocellular cancer were observed (5.8{\%}), with a mean time interval from treatment to progression of 54.6 months (range 4-146 months). The rate of progression was significantly higher in women diagnosed with VaIN3 compared with VaIN2 (15.4{\%} vs. 1.4{\%}, p < 0.0001). Women with HG-VaIN and with previous hysterectomy showed a significantly higher rate of progression to invasive vaginal cancer compared to non-hysterectomised women (16.7{\%} vs. 1.4{\%}, p < 0.0001). A higher risk of progression for women with VaIN3 and for women with previous hysterectomy for cervical HPV-related disease was confirmed by multivariable logistic regression analysis.CONCLUSIONS: A higher rate of progression to vaginal cancer was reported in women diagnosed with VaIN3 on biopsy and in women with previous hysterectomy for HPV-related cervical disease. These patients should be considered at higher risk, thus a long lasting and accurate follow up is recommended.",
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author = "F Sopracordevole and M. Barbero and Nausicaa Clemente and Fallani, {M. G.} and P. Cattani and A. Agarossi and {De Piero}, G. and A. Parin and A. Frega and F. Boselli and Francesca Mancioli and M Buttignol and Francesca Currado and Pieralli, {A. L.} and A. Ciavattini and {Italian Society of Colposcopy and Cervico-Vaginal Pathology (SICPCV)}",
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T1 - High-grade vaginal intraepithelial neoplasia and risk of progression to vaginal cancer

T2 - a multicentre study of the Italian Society of Colposcopy and Cervico-Vaginal Pathology (SICPCV)

AU - Sopracordevole, F

AU - Barbero, M.

AU - Clemente, Nausicaa

AU - Fallani, M. G.

AU - Cattani, P.

AU - Agarossi, A.

AU - De Piero, G.

AU - Parin, A.

AU - Frega, A.

AU - Boselli, F.

AU - Mancioli, Francesca

AU - Buttignol, M

AU - Currado, Francesca

AU - Pieralli, A. L.

AU - Ciavattini, A.

AU - Italian Society of Colposcopy and Cervico-Vaginal Pathology (SICPCV)

PY - 2016/3

Y1 - 2016/3

N2 - OBJECTIVE: The aim of this study was to analyse the women with high grade vaginal intraepithelial neoplasia (HG-VaIN), in order to identify a subset of women at higher risk of progression to invasive vaginal cancer.MATERIALS AND METHODS: The medical records of all the women diagnosed with HG-VaIN, and subsequently treated, from January 1995 to December 2013 were analyzed in a multicentre retrospective case series. The rate of progression to invasive vaginal cancer and the potential risk factors were evaluated.RESULTS: 205 women with biopsy diagnosis of HG-VaIN were considered, with a mean follow up of 57 months (range 4-254 months). 12 cases of progression to vaginal squamocellular cancer were observed (5.8%), with a mean time interval from treatment to progression of 54.6 months (range 4-146 months). The rate of progression was significantly higher in women diagnosed with VaIN3 compared with VaIN2 (15.4% vs. 1.4%, p < 0.0001). Women with HG-VaIN and with previous hysterectomy showed a significantly higher rate of progression to invasive vaginal cancer compared to non-hysterectomised women (16.7% vs. 1.4%, p < 0.0001). A higher risk of progression for women with VaIN3 and for women with previous hysterectomy for cervical HPV-related disease was confirmed by multivariable logistic regression analysis.CONCLUSIONS: A higher rate of progression to vaginal cancer was reported in women diagnosed with VaIN3 on biopsy and in women with previous hysterectomy for HPV-related cervical disease. These patients should be considered at higher risk, thus a long lasting and accurate follow up is recommended.

AB - OBJECTIVE: The aim of this study was to analyse the women with high grade vaginal intraepithelial neoplasia (HG-VaIN), in order to identify a subset of women at higher risk of progression to invasive vaginal cancer.MATERIALS AND METHODS: The medical records of all the women diagnosed with HG-VaIN, and subsequently treated, from January 1995 to December 2013 were analyzed in a multicentre retrospective case series. The rate of progression to invasive vaginal cancer and the potential risk factors were evaluated.RESULTS: 205 women with biopsy diagnosis of HG-VaIN were considered, with a mean follow up of 57 months (range 4-254 months). 12 cases of progression to vaginal squamocellular cancer were observed (5.8%), with a mean time interval from treatment to progression of 54.6 months (range 4-146 months). The rate of progression was significantly higher in women diagnosed with VaIN3 compared with VaIN2 (15.4% vs. 1.4%, p < 0.0001). Women with HG-VaIN and with previous hysterectomy showed a significantly higher rate of progression to invasive vaginal cancer compared to non-hysterectomised women (16.7% vs. 1.4%, p < 0.0001). A higher risk of progression for women with VaIN3 and for women with previous hysterectomy for cervical HPV-related disease was confirmed by multivariable logistic regression analysis.CONCLUSIONS: A higher rate of progression to vaginal cancer was reported in women diagnosed with VaIN3 on biopsy and in women with previous hysterectomy for HPV-related cervical disease. These patients should be considered at higher risk, thus a long lasting and accurate follow up is recommended.

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KW - Aged

KW - Carcinoma in Situ

KW - Colposcopy

KW - Disease Progression

KW - Female

KW - Follow-Up Studies

KW - Humans

KW - Italy

KW - Middle Aged

KW - Neoplasm Grading

KW - Pregnancy

KW - Retrospective Studies

KW - Risk Factors

KW - Vaginal Neoplasms

KW - Journal Article

KW - Multicenter Study

M3 - Article

C2 - 27010135

VL - 20

SP - 818

EP - 824

JO - European Review for Medical and Pharmacological Sciences

JF - European Review for Medical and Pharmacological Sciences

SN - 1128-3602

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ER -