High-grade vaginal intraepithelial neoplasia and risk of progression to vaginal cancer: a multicentre study of the Italian Society of Colposcopy and Cervico-Vaginal Pathology (SICPCV)

F Sopracordevole, M. Barbero, Nausicaa Clemente, M. G. Fallani, P. Cattani, A. Agarossi, G. De Piero, A. Parin, A. Frega, F. Boselli, Francesca Mancioli, M Buttignol, Francesca Currado, A. L. Pieralli, A. Ciavattini, Italian Society of Colposcopy and Cervico-Vaginal Pathology (SICPCV)

Research output: Contribution to journalArticle

Abstract

OBJECTIVE: The aim of this study was to analyse the women with high grade vaginal intraepithelial neoplasia (HG-VaIN), in order to identify a subset of women at higher risk of progression to invasive vaginal cancer.

MATERIALS AND METHODS: The medical records of all the women diagnosed with HG-VaIN, and subsequently treated, from January 1995 to December 2013 were analyzed in a multicentre retrospective case series. The rate of progression to invasive vaginal cancer and the potential risk factors were evaluated.

RESULTS: 205 women with biopsy diagnosis of HG-VaIN were considered, with a mean follow up of 57 months (range 4-254 months). 12 cases of progression to vaginal squamocellular cancer were observed (5.8%), with a mean time interval from treatment to progression of 54.6 months (range 4-146 months). The rate of progression was significantly higher in women diagnosed with VaIN3 compared with VaIN2 (15.4% vs. 1.4%, p < 0.0001). Women with HG-VaIN and with previous hysterectomy showed a significantly higher rate of progression to invasive vaginal cancer compared to non-hysterectomised women (16.7% vs. 1.4%, p < 0.0001). A higher risk of progression for women with VaIN3 and for women with previous hysterectomy for cervical HPV-related disease was confirmed by multivariable logistic regression analysis.

CONCLUSIONS: A higher rate of progression to vaginal cancer was reported in women diagnosed with VaIN3 on biopsy and in women with previous hysterectomy for HPV-related cervical disease. These patients should be considered at higher risk, thus a long lasting and accurate follow up is recommended.

Original languageEnglish
Pages (from-to)818-24
Number of pages7
JournalEuropean Review for Medical and Pharmacological Sciences
Volume20
Issue number5
Publication statusPublished - Mar 2016

Keywords

  • Adult
  • Aged
  • Carcinoma in Situ
  • Colposcopy
  • Disease Progression
  • Female
  • Follow-Up Studies
  • Humans
  • Italy
  • Middle Aged
  • Neoplasm Grading
  • Pregnancy
  • Retrospective Studies
  • Risk Factors
  • Vaginal Neoplasms
  • Journal Article
  • Multicenter Study

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  • Cite this

    Sopracordevole, F., Barbero, M., Clemente, N., Fallani, M. G., Cattani, P., Agarossi, A., De Piero, G., Parin, A., Frega, A., Boselli, F., Mancioli, F., Buttignol, M., Currado, F., Pieralli, A. L., Ciavattini, A., & Italian Society of Colposcopy and Cervico-Vaginal Pathology (SICPCV) (2016). High-grade vaginal intraepithelial neoplasia and risk of progression to vaginal cancer: a multicentre study of the Italian Society of Colposcopy and Cervico-Vaginal Pathology (SICPCV). European Review for Medical and Pharmacological Sciences, 20(5), 818-24.