Abstract
OBJECTIVE: The aim of this study was to analyse the women with high grade vaginal intraepithelial neoplasia (HG-VaIN), in order to identify a subset of women at higher risk of progression to invasive vaginal cancer.
MATERIALS AND METHODS: The medical records of all the women diagnosed with HG-VaIN, and subsequently treated, from January 1995 to December 2013 were analyzed in a multicentre retrospective case series. The rate of progression to invasive vaginal cancer and the potential risk factors were evaluated.
RESULTS: 205 women with biopsy diagnosis of HG-VaIN were considered, with a mean follow up of 57 months (range 4-254 months). 12 cases of progression to vaginal squamocellular cancer were observed (5.8%), with a mean time interval from treatment to progression of 54.6 months (range 4-146 months). The rate of progression was significantly higher in women diagnosed with VaIN3 compared with VaIN2 (15.4% vs. 1.4%, p < 0.0001). Women with HG-VaIN and with previous hysterectomy showed a significantly higher rate of progression to invasive vaginal cancer compared to non-hysterectomised women (16.7% vs. 1.4%, p < 0.0001). A higher risk of progression for women with VaIN3 and for women with previous hysterectomy for cervical HPV-related disease was confirmed by multivariable logistic regression analysis.
CONCLUSIONS: A higher rate of progression to vaginal cancer was reported in women diagnosed with VaIN3 on biopsy and in women with previous hysterectomy for HPV-related cervical disease. These patients should be considered at higher risk, thus a long lasting and accurate follow up is recommended.
| Original language | English |
|---|---|
| Pages (from-to) | 818-24 |
| Number of pages | 7 |
| Journal | European Review for Medical and Pharmacological Sciences |
| Volume | 20 |
| Issue number | 5 |
| Publication status | Published - Mar 2016 |
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Keywords
- Adult
- Aged
- Carcinoma in Situ
- Colposcopy
- Disease Progression
- Female
- Follow-Up Studies
- Humans
- Italy
- Middle Aged
- Neoplasm Grading
- Pregnancy
- Retrospective Studies
- Risk Factors
- Vaginal Neoplasms
- Journal Article
- Multicenter Study
Cite this
High-grade vaginal intraepithelial neoplasia and risk of progression to vaginal cancer : a multicentre study of the Italian Society of Colposcopy and Cervico-Vaginal Pathology (SICPCV). / Sopracordevole, F; Barbero, M.; Clemente, Nausicaa; Fallani, M. G.; Cattani, P.; Agarossi, A.; De Piero, G.; Parin, A.; Frega, A.; Boselli, F.; Mancioli, Francesca; Buttignol, M; Currado, Francesca; Pieralli, A. L.; Ciavattini, A.; Italian Society of Colposcopy and Cervico-Vaginal Pathology (SICPCV).
In: European Review for Medical and Pharmacological Sciences, Vol. 20, No. 5, 03.2016, p. 818-24.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - High-grade vaginal intraepithelial neoplasia and risk of progression to vaginal cancer
T2 - a multicentre study of the Italian Society of Colposcopy and Cervico-Vaginal Pathology (SICPCV)
AU - Sopracordevole, F
AU - Barbero, M.
AU - Clemente, Nausicaa
AU - Fallani, M. G.
AU - Cattani, P.
AU - Agarossi, A.
AU - De Piero, G.
AU - Parin, A.
AU - Frega, A.
AU - Boselli, F.
AU - Mancioli, Francesca
AU - Buttignol, M
AU - Currado, Francesca
AU - Pieralli, A. L.
AU - Ciavattini, A.
AU - Italian Society of Colposcopy and Cervico-Vaginal Pathology (SICPCV)
PY - 2016/3
Y1 - 2016/3
N2 - OBJECTIVE: The aim of this study was to analyse the women with high grade vaginal intraepithelial neoplasia (HG-VaIN), in order to identify a subset of women at higher risk of progression to invasive vaginal cancer.MATERIALS AND METHODS: The medical records of all the women diagnosed with HG-VaIN, and subsequently treated, from January 1995 to December 2013 were analyzed in a multicentre retrospective case series. The rate of progression to invasive vaginal cancer and the potential risk factors were evaluated.RESULTS: 205 women with biopsy diagnosis of HG-VaIN were considered, with a mean follow up of 57 months (range 4-254 months). 12 cases of progression to vaginal squamocellular cancer were observed (5.8%), with a mean time interval from treatment to progression of 54.6 months (range 4-146 months). The rate of progression was significantly higher in women diagnosed with VaIN3 compared with VaIN2 (15.4% vs. 1.4%, p < 0.0001). Women with HG-VaIN and with previous hysterectomy showed a significantly higher rate of progression to invasive vaginal cancer compared to non-hysterectomised women (16.7% vs. 1.4%, p < 0.0001). A higher risk of progression for women with VaIN3 and for women with previous hysterectomy for cervical HPV-related disease was confirmed by multivariable logistic regression analysis.CONCLUSIONS: A higher rate of progression to vaginal cancer was reported in women diagnosed with VaIN3 on biopsy and in women with previous hysterectomy for HPV-related cervical disease. These patients should be considered at higher risk, thus a long lasting and accurate follow up is recommended.
AB - OBJECTIVE: The aim of this study was to analyse the women with high grade vaginal intraepithelial neoplasia (HG-VaIN), in order to identify a subset of women at higher risk of progression to invasive vaginal cancer.MATERIALS AND METHODS: The medical records of all the women diagnosed with HG-VaIN, and subsequently treated, from January 1995 to December 2013 were analyzed in a multicentre retrospective case series. The rate of progression to invasive vaginal cancer and the potential risk factors were evaluated.RESULTS: 205 women with biopsy diagnosis of HG-VaIN were considered, with a mean follow up of 57 months (range 4-254 months). 12 cases of progression to vaginal squamocellular cancer were observed (5.8%), with a mean time interval from treatment to progression of 54.6 months (range 4-146 months). The rate of progression was significantly higher in women diagnosed with VaIN3 compared with VaIN2 (15.4% vs. 1.4%, p < 0.0001). Women with HG-VaIN and with previous hysterectomy showed a significantly higher rate of progression to invasive vaginal cancer compared to non-hysterectomised women (16.7% vs. 1.4%, p < 0.0001). A higher risk of progression for women with VaIN3 and for women with previous hysterectomy for cervical HPV-related disease was confirmed by multivariable logistic regression analysis.CONCLUSIONS: A higher rate of progression to vaginal cancer was reported in women diagnosed with VaIN3 on biopsy and in women with previous hysterectomy for HPV-related cervical disease. These patients should be considered at higher risk, thus a long lasting and accurate follow up is recommended.
KW - Adult
KW - Aged
KW - Carcinoma in Situ
KW - Colposcopy
KW - Disease Progression
KW - Female
KW - Follow-Up Studies
KW - Humans
KW - Italy
KW - Middle Aged
KW - Neoplasm Grading
KW - Pregnancy
KW - Retrospective Studies
KW - Risk Factors
KW - Vaginal Neoplasms
KW - Journal Article
KW - Multicenter Study
M3 - Article
C2 - 27010135
VL - 20
SP - 818
EP - 824
JO - European Review for Medical and Pharmacological Sciences
JF - European Review for Medical and Pharmacological Sciences
SN - 1128-3602
IS - 5
ER -